Also known as: 1,2-Ethanediamine, 4-04-00-01166, Algicode 106L, Amerstat 274, beta-Aminoethylamine (+15 more)
CAS 107-15-3
Ethylenediamine (CAS 107-15-3) is a chemical substance with GHS signal word Danger; key hazard signal: H226; H312; H302; H314; H334; H317. Key regulatory status: SVHC Candidate List, REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ECHA SVHC, ILO ICSC, OSHA.
Ethylenediamine is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H312, H302, H314, H334, H317).
CAS, identifiers, formula, and alternate names for the matched substance record.
Candidate List status and reason under the ECHA REACH SVHC program.
| Substance | Reason | Included |
|---|---|---|
| Ethylenediamine | Respiratory sensitising properties (Article 57(f) - human health) | 27-Jun-2018 |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B; Resp. Sens. 1; Skin Sens. 1 | H226; H312; H302; H314; H334; H317 | GHS02; GHS07; GHS05; GHS08 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Flammable liquid and vapour Harmful if swallowed or in contact with skin Causes severe skin burns and eye damage May cause an allergic skin reaction May cause allergy or asthma symptoms or breathing difficulties if inhaled |
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. |
| Long-term Effects | Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 10 ppm (25 mg/m³) | 10 | 25 | N |
| NIOSH | TWA | 10 ppm (25 mg/m³) | 10 | 25 | N |
| ACGIH | TWA | 10 ppm [1990] | 10 | - | Y |
| CAL/OSHA | TWA | 10 ppm (25 mg/m³) | 10 | 25 | N |
| NIOSH | IDLH | 1000 ppm | 1000 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.023 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.023 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.15 | mg/kg bw/day | ARfD | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.15 | mg/kg bw/day | ARfD | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| 13 | min | Breakthrough Time | Dermal | - | NTP_ICE_skin_irritation |
| 208.3 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 24.749 | ug/mL | CD86, EC120 | Dermal | - | NTP_ICE_skin_sensitization |
| 16.11 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 47 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 78.3 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 81.1 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 91.2 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 109 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 109.2 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 173.6 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 265.7 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 58.44 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| 200 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 271.7 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 300 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| =25 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 3.4 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 18.6 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| -0.3 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.7 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.3 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 1.7 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 9.65 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 99.88 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 549 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| >750 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 2.2 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 2.2 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 2.2 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 2.2 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 453.4 | uM | EC3 | Dermal | - | NTP_ICE_skin_sensitization |
| 60V9STC53F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 60V9STC53F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 60V9STC53F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 60V9STC53F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1793 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| >2000 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 1.116 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 7.64 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 13.19 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 7.35 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 14.7 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =61452.2 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =100 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 50 of 71 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Ethylenediamine | 203-468-6 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS food additive, ADI, and GRAS records where available.
1 food-safety record found.
View full food safety profile →Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Ethylenediamine (CAS 107-15-3) is classified under EU CLP Annex VI as Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B; Resp. Sens. 1; Skin Sens. 1 with signal word Danger. Hazard statements: H226; H312; H302; H314; H334; H317. Source: EU CLP Annex VI (ECHA).
Ethylenediamine has 71 NOAEL studies in the database. The lowest reported value is -0.3 % via Dermal. Source: NTP_ICE_skin_sensitization.
Ethylenediamine appears on 6 regulatory/inventory lists including pharmaceutical, active_ingredient; Europe; Pesticides, drinking_water; Europe; manufacturing; plastic_additive, and 3 more. Source: EPA CPDat.
Yes, Ethylenediamine is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: Respiratory sensitising properties (Article 57(f) - human health). Source: ECHA SVHC Candidate List.
Occupational exposure limits for Ethylenediamine are set by OSHA, NIOSH, ACGIH. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Ethylenediamine is also indexed as a cosmetic ingredient under the name Ethylenediamine ⚠️. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ECHA SVHC Candidate List, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Ethylenediamine is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H312, H302, H314, H334, H317).
Ethylenediamine also appears in cosmetics, pharmaceutical, food safety, cannabis databases.