Danger ?GHS08GHS06GHS05 NOAEL Data IARC Group 3 REACH Registered Cosmetic Ingredient

Phenol

Also known as: Baker's P & S liquid & Ointment, Baker's P and S Liquid and Ointment, Caswell No. 649, EINECS 203-632-7, EPA Pesticide Chemical Code 064001 (+15 more)

CAS 108-95-2

Phenol (CAS 108-95-2) is a chemical substance with GHS signal word Danger; key hazard signal: H341; H331; H311; H301; H373 **; H314. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for Phenol →

SOURCE noael studies public
NOAEL studies
100
SOURCE chemical inventory jurisdictions
Regulatory lists
60
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields
Name
Phenol
CAS Number
108-95-2
DTXSID
DTXSID5021124
Molecular Formula
C6H6O
InChI Key
ISWSIDIOOBJBQZ-UHFFFAOYSA-N
Monoisotopic Mass
94.041865
Synonyms
Baker's P & S liquid & OintmentBaker's P and S Liquid and OintmentCaswell No. 649EINECS 203-632-7EPA Pesticide Chemical Code 064001FEMA No. 3223NCI-C50124Phenol, liquefiedRCRA waste number U188UNII-339NCG44TVBenzophenolCampho-phenique cold sore gel

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records
GroupMeaningEvaluatedVolume
Group 3Not classifiable199847, 71

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Muta. 2; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; STOT RE 2 *; Skin Corr. 1BH341; H331; H311; H301; H373 **; H314?; GHS08; GHS06; GHS05Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
GHS Signal WordDANGER
GHS Hazard StatementsToxic if swallowed or in contact with skin Causes severe skin burns and eye damage Suspected of causing genetic defects Causes damage to central nervous system, the heart and kidneys Causes damage to organs through prolonged or repeated exposure May cause respiratory irritation Toxic to aquatic life
Short-term EffectsThe substance and the vapour are corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. See Notes. The substance may cause effects on the central nervous system, heart and kidneys. This may result in convulsions, coma, cardiac disorders, respiratory failure and collapse. The effects may be delayed. Medical observation is indicated. Exposure could cause death.
Long-term EffectsThe substance may have effects on the liver, kidneys and nervous system.
Routes of ExposureSerious local effects by all routes of exposure.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 9 records
AgencyMetricValueppmmg/m3Skin
OSHATWA5 ppm (19mg/m³)519Y
NIOSHTWA5 ppm (19 mg/m³)519Y
NIOSHCEILING15.6 ppm (60 mg/m³) [15 minutes]15.660Y
ACGIHTWA5 ppm [1992]5-Y
CAL/OSHATWA5 ppm (19 mg/m³)519Y
NIOSHIDLH250 ppm250--
AIHAERPG-110 ppm10--
AIHAERPG-250 ppm50--
AIHAERPG-3200 ppm200--

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 55 records
BiocidePreservativeDeodorizerFlavouring and nutrientFragranceAbrasivePharmaceuticalHardenerMonomersAntioxidantChemical reaction regulator

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 60 records
ListKeywordSource
air; Cons electronics mech appliances and machinery; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesCalifornia Department of Pesticide RegulationState of California
Cons electronics mech appliances and machinery; EuropeDanish Environmental Protection AgencyDanish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
Cons electronics mech appliances and machinery; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
artificial_sweat; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
artificial_sweat; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts adhesive; detected; EuropeDanish Environmental Protection AgencyDanish EPA
air; Arts and crafts/Office supplies - fabric treatment and dye; Arts and crafts/Office supplies - home office - pens and markers; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
artificial_saliva; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
detected; wastewaterUSGSUnited States Geological Survey (USGS)
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; animal_products; Europe; pharmaceutical; residueEUCPCat
detected; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
detected; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
air; Cons electronics mech appliances and machinery; emissions; Europe; Toys and children's productsMinistry of Environment and Food of Denmark; Environmental Protection AgencyDanish EPA
Cleaning products and household care - air freshener; EuropeDanish Environmental Protection AgencyDanish EPA
air; Cleaning products and household care - air freshener; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
air; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
range:0-0.20.2mg/kg bw/dayADI--INCHEM_WHO_jecfa_jecmono_v46je09
range:0-0.20.2mg/kg bw/dayADI--INCHEM_WHO_jecfa_jecmono_v46je09
range:0-0.40.4mg/kg bw/dayADI--INCHEM_WHO_jecfa_jecmono_v46je09
range:0-0.40.4mg/kg bw/dayADI--INCHEM_WHO_jecfa_jecmono_v46je09
=157mg/kg bw/dayBMDoralRatToxValDB_IRIS
=93mg/kg bw/dayBMDLoralRatToxValDB_IRIS
=93mg/kg/dayBMDLoral-EPA_IRIS_iris_rfd_systems.csv
=125mg/kg bw/dayBMDLoralRatToxValDB_ATSDR_MRLs
=52mg/kg bw/dayBMDL (10)oralRatToxValDB_EFSA
130.2ug/mLCD54, EC200Dermal-NTP_ICE_skin_sensitization
21.74ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
173ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
101.68ug/mLCV70Dermal-NTP_ICE_skin_sensitization
308.8ug/mLCV75Dermal-NTP_ICE_skin_sensitization
5.496uL/min/10^6 cellsClint-HumanNTP_ICE_adme_parameters
=8mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
>2000uMEC1.5Dermal-NTP_ICE_skin_sensitization
339NCG44TVUNIIFDA UNII substance identifier--openFDA substances
339NCG44TVUNIIFDA UNII substance identifier--openFDA substances
339NCG44TVUNIIFDA UNII substance identifier--openFDA substances
339NCG44TVUNIIFDA UNII substance identifier--openFDA substances
conceptidentifierFDA UNII substance identifier--openFDA substances
conceptidentifierFDA UNII substance identifier--openFDA substances
conceptidentifierFDA UNII substance identifier--openFDA substances
conceptidentifierFDA UNII substance identifier--openFDA substances
0.6201fractionFu-HumanNTP_ICE_adme_parameters
3IARC groupIARC carcinogenicity classification--IARC Monographs
3IARC groupIARC carcinogenicity classification--IARC Monographs
3IARC groupIARC carcinogenicity classification--IARC Monographs
3unitlessIARC group--NTP_ICE_cancer
1.3ratioImaxDermal-NTP_ICE_skin_sensitization
-%Incidence of positive responsesDermalHumanNTP_ICE_skin_sensitization
1241ug/cm2Induction dose per skin areaDermalHumanNTP_ICE_skin_sensitization
0.316mg/LLC50Inhalation-NTP_ICE_acute_inhalation
=316mg/kg bwLD50oralRatNTP_ICE_acute_oral
=317mg/kg bwLD50oralRatNTP_ICE_acute_oral
=340mg/kg bwLD50oralRatNTP_ICE_acute_oral
=400mg/kg bwLD50oralRatNTP_ICE_acute_oral
>410mg/kg bwLD50oralRatNTP_ICE_acute_oral
=414mg/kg bwLD50oralRatNTP_ICE_acute_oral
=445mg/kg bwLD50oralRatNTP_ICE_acute_oral
=512mg/kg bwLD50oralRatNTP_ICE_acute_oral
=520mg/kg bwLD50oralRatNTP_ICE_acute_oral
=527mg/kg bwLD50oralRatNTP_ICE_acute_oral
=530mg/kg bwLD50oralRatNTP_ICE_acute_oral
=540mg/kg bwLD50oralRatNTP_ICE_acute_oral
=550mg/kg bwLD50oralRatNTP_ICE_acute_oral
=650mg/kg bwLD50oralRatNTP_ICE_acute_oral
=1030mg/kg bwLD50oralRatNTP_ICE_acute_oral
=1500mg/kg bwLD50oralRatNTP_ICE_acute_oral

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredPhenol203-632-7ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records
ChemicalCategoryFlags
Phenol--

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
restricted
Max
0.2%
Category
Fragrance
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL PHENOL
ChEMBL Phase
4
Adverse Events
142
Bioactivity
20
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Phenol?

Phenol (CAS 108-95-2) is classified under EU CLP Annex VI as Muta. 2; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; STOT RE 2 *; Skin Corr. 1B with signal word Danger. Hazard statements: H341; H331; H311; H301; H373 **; H314. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Phenol?

Phenol has 100 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.

What regulatory lists include Phenol?

Phenol appears on 24 regulatory/inventory lists including air; Cons electronics mech appliances and machinery; detected; emissions; Europe, active_ingredient; Pesticides, Cons electronics mech appliances and machinery; Europe, and 21 more. Source: EPA CPDat.

Is Phenol a carcinogen according to IARC?

Phenol is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

What are the occupational exposure limits for Phenol?

Occupational exposure limits for Phenol are set by OSHA, NIOSH, ACGIH. 9 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Phenol used in cosmetics?

Yes, Phenol is also indexed as a cosmetic ingredient under the name Phenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Phenol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Phenol have different safety status in cosmetics vs industrial chemicals?

Phenol is classified GHS Danger (H341, H331, H311, H301, H373, H314) in the chemicals database but is restricted in EU cosmetics at max 0.2%.

Is Phenol used outside industrial chemicals?

Phenol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.