Danger ?GHS08GHS06GHS05 NOAEL Data IARC Group 3 REACH Registered Cosmetic Ingredient

Phenol

Also known as: Baker's P & S liquid & Ointment, Baker's P and S Liquid and Ointment, Caswell No. 649, EINECS 203-632-7, EPA Pesticide Chemical Code 064001 (+15 more)

CAS 108-95-2

Phenol (CAS 108-95-2) is a chemical substance with GHS signal word Danger; key hazard signal: H341; H331; H311; H301; H373 **; H314. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for Phenol →

Cross-Vertical Regulatory Divergence

Phenol is classified GHS Danger (H341, H331, H311, H301, H373, H314) in the chemicals database but is restricted in EU cosmetics at max 0.2%.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

100

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

Phenol

CAS Number

108-95-2

DTXSID

DTXSID5021124

Molecular Formula

C6H6O

InChI Key

ISWSIDIOOBJBQZ-UHFFFAOYSA-N

Monoisotopic Mass

94.041865

Synonyms

Baker's P & S liquid & OintmentBaker's P and S Liquid and OintmentCaswell No. 649EINECS 203-632-7EPA Pesticide Chemical Code 064001FEMA No. 3223NCI-C50124Phenol, liquefiedRCRA waste number U188UNII-339NCG44TVBenzophenolCampho-phenique cold sore gel

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 3	Not classifiable	1998	47, 71

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Muta. 2; Acute Tox. 3 ; Acute Tox. 3 ; Acute Tox. 3 ; STOT RE 2 ; Skin Corr. 1B	H341; H331; H311; H301; H373 **; H314	?; GHS08; GHS06; GHS05	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Toxic if swallowed or in contact with skin Causes severe skin burns and eye damage Suspected of causing genetic defects Causes damage to central nervous system, the heart and kidneys Causes damage to organs through prolonged or repeated exposure May cause respiratory irritation Toxic to aquatic life
Short-term Effects	The substance and the vapour are corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. See Notes. The substance may cause effects on the central nervous system, heart and kidneys. This may result in convulsions, coma, cardiac disorders, respiratory failure and collapse. The effects may be delayed. Medical observation is indicated. Exposure could cause death.
Long-term Effects	The substance may have effects on the liver, kidneys and nervous system.
Routes of Exposure	Serious local effects by all routes of exposure.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 9 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	5 ppm (19mg/m³)	5	19	Y
NIOSH	TWA	5 ppm (19 mg/m³)	5	19	Y
NIOSH	CEILING	15.6 ppm (60 mg/m³) [15 minutes]	15.6	60	Y
ACGIH	TWA	5 ppm [1992]	5	-	Y
CAL/OSHA	TWA	5 ppm (19 mg/m³)	5	19	Y
NIOSH	IDLH	250 ppm	250	-	-
AIHA	ERPG-1	10 ppm	10	-	-
AIHA	ERPG-2	50 ppm	50	-	-
AIHA	ERPG-3	200 ppm	200	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 55 records

BiocidePreservativeDeodorizerFlavouring and nutrientFragranceAbrasivePharmaceuticalHardenerMonomersAntioxidantChemical reaction regulator

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 60 records

List	Keyword	Source
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
Cons electronics mech appliances and machinery; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
artificial_sweat; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
artificial_sweat; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts adhesive; detected; Europe	Danish Environmental Protection Agency	Danish EPA
air; Arts and crafts/Office supplies - fabric treatment and dye; Arts and crafts/Office supplies - home office - pens and markers; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
artificial_saliva; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; wastewater	USGS	United States Geological Survey (USGS)
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; animal_products; Europe; pharmaceutical; residue	EU	CPCat
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; emissions; Europe; Toys and children's products	Ministry of Environment and Food of Denmark; Environmental Protection Agency	Danish EPA
Cleaning products and household care - air freshener; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cleaning products and household care - air freshener; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies

Value	Unit	Endpoint	Route	Species	Source
range:0-0.20.2	mg/kg bw/day	ADI	-	-	INCHEM_WHO_jecfa_jecmono_v46je09
range:0-0.20.2	mg/kg bw/day	ADI	-	-	INCHEM_WHO_jecfa_jecmono_v46je09
range:0-0.40.4	mg/kg bw/day	ADI	-	-	INCHEM_WHO_jecfa_jecmono_v46je09
range:0-0.40.4	mg/kg bw/day	ADI	-	-	INCHEM_WHO_jecfa_jecmono_v46je09
=157	mg/kg bw/day	BMD	oral	Rat	ToxValDB_IRIS
=93	mg/kg bw/day	BMDL	oral	Rat	ToxValDB_IRIS
=93	mg/kg/day	BMDL	oral	-	EPA_IRIS_iris_rfd_systems.csv
=125	mg/kg bw/day	BMDL	oral	Rat	ToxValDB_ATSDR_MRLs
=52	mg/kg bw/day	BMDL (10)	oral	Rat	ToxValDB_EFSA
130.2	ug/mL	CD54, EC200	Dermal	-	NTP_ICE_skin_sensitization
21.74	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
173	ug/mL	CD86, EC150	Dermal	-	NTP_ICE_skin_sensitization
101.68	ug/mL	CV70	Dermal	-	NTP_ICE_skin_sensitization
308.8	ug/mL	CV75	Dermal	-	NTP_ICE_skin_sensitization
5.496	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
=8	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
>2000	uM	EC1.5	Dermal	-	NTP_ICE_skin_sensitization
339NCG44TV	UNII	FDA UNII substance identifier	-	-	openFDA substances
339NCG44TV	UNII	FDA UNII substance identifier	-	-	openFDA substances
339NCG44TV	UNII	FDA UNII substance identifier	-	-	openFDA substances
339NCG44TV	UNII	FDA UNII substance identifier	-	-	openFDA substances
concept	identifier	FDA UNII substance identifier	-	-	openFDA substances
concept	identifier	FDA UNII substance identifier	-	-	openFDA substances
concept	identifier	FDA UNII substance identifier	-	-	openFDA substances
concept	identifier	FDA UNII substance identifier	-	-	openFDA substances
0.6201	fraction	Fu	-	Human	NTP_ICE_adme_parameters
3	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
3	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
3	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
3	unitless	IARC group	-	-	NTP_ICE_cancer
1.3	ratio	Imax	Dermal	-	NTP_ICE_skin_sensitization
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
1241	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
0.316	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=316	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=317	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=340	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=400	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
>410	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=414	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=445	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=512	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=520	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=527	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=530	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=540	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=550	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=650	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=1030	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=1500	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Phenol	203-632-7	ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records

Chemical	Category	Flags
Phenol	-	-

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

0.2%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL PHENOL

ChEMBL Phase

Adverse Events

142

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Phenol?

Phenol (CAS 108-95-2) is classified under EU CLP Annex VI as Muta. 2; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; STOT RE 2 *; Skin Corr. 1B with signal word Danger. Hazard statements: H341; H331; H311; H301; H373 **; H314. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Phenol?

Phenol has 100 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.

What regulatory lists include Phenol?

Phenol appears on 24 regulatory/inventory lists including air; Cons electronics mech appliances and machinery; detected; emissions; Europe, active_ingredient; Pesticides, Cons electronics mech appliances and machinery; Europe, and 21 more. Source: EPA CPDat.

Is Phenol a carcinogen according to IARC?

Phenol is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

What are the occupational exposure limits for Phenol?

Occupational exposure limits for Phenol are set by OSHA, NIOSH, ACGIH. 9 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Phenol used in cosmetics?

Yes, Phenol is also indexed as a cosmetic ingredient under the name Phenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Phenol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Phenol have different safety status in cosmetics vs industrial chemicals?

Phenol is classified GHS Danger (H341, H331, H311, H301, H373, H314) in the chemicals database but is restricted in EU cosmetics at max 0.2%.

Is Phenol used outside industrial chemicals?

Phenol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.