What is the GHS hazard classification for Fumaric acid?
Fumaric acid (CAS 110-17-8) is classified under EU CLP Annex VI as Eye Irrit. 2 with signal word Warning. Hazard statements: H319. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
Fumaric acid
Also known as: (2E)-2-Butenedioic acid, trans-Butenedioic acid, 4-02-00-02202, Allomalenic acid, BRN 0605763 (+15 more)
CAS 110-17-8
Fumaric acid (CAS 110-17-8) is a chemical substance with GHS signal word Warning; key hazard signal: H319. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
NOAEL studies
NOAEL studies
28
SOURCE
Chemical inventory jurisdictions
Regulatory lists
12
SOURCE
EU CLP Annex VI
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Fumaric acid
CAS Number
110-17-8
Molecular Formula
C4H4O4
InChI Key
VZCYOOQTPOCHFL-OWOJBTEDSA-N
Monoisotopic Mass
116.010959
Synonyms
(2E)-2-Butenedioic acidtrans-Butenedioic acid4-02-00-02202Allomalenic acidBRN 0605763Butenedioic acid, (E)-Caswell No. 465EEINECS 203-743-0EPA Pesticide Chemical Code 0512011,2-Ethenedicarboxylic acid, trans-FEMA No. 2488FEMA Number 2488
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Eye Irrit. 2 | H319 | GHS07 | Warning |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Causes eye irritation Harmful to aquatic life |
| Short-term Effects | The substance is irritating to the eyes. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
25 records
Dispersing agentpH regulating agentFragranceFlavouring and nutrientPharmaceuticalFixing agent (mordant)Processing aids not otherwise specifiedChemical reaction regulatorBiocideLeavening agentFood preservative
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
12 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| fracking; water | NY Department of Conservation | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 28 of 28 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1250 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| =42.32 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 10.8 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 4.6 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 7.7 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| >2000 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 88XHZ13131 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2400 | uM | IC50 | Dermal | - | NTP ICE skin sensitization |
| 1.2 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| 1.274 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| 1.3 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| >1.306 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| =1 | % in diet | NOAEL | oral | rat | CIR Safety Assessment |
| =1.2 | % in diet | NOAEL | oral | rat | CIR Safety Assessment |
| =5 | % of diet | NOAEL | oral | dog | CIR Safety Assessment |
| =6.9 | % in diet | NOAEL | oral | rabbit | CIR Safety Assessment |
| 400 | mg/kg bw/day | NOAEL | oral | guinea pig | COSMOS DB |
| >400 | mg/kg bw/day | NOAEL | oral | Guinea Pig | ECHA |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =500 | mg/kg | NOAEL | intravenous | rabbit | CIR Safety Assessment |
| 600 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| ~600 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| 1250 | mg/kg bw/day | NOAEL | oral | dog | COSMOS DB |
| 1500 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS DB |
| 2070 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS DB |
| =2080 | mg/kg bw/day | NOAEL | oral | rabbit | CIR Safety Assessment |
| 2786 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
Showing 28 of 28 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Fumaric acid | 203-743-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
buffering agent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
FUMARIC ACID
ChEMBL Phase
3
Adverse Events
0
Bioactivity
6
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
E297 — ADI: 6 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Fumaric acid?
Fumaric acid has 28 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.
What regulatory lists include Fumaric acid?
Fumaric acid appears on 11 regulatory/inventory lists including Indirect additives food contact (10/2018), drinking_water; Europe; manufacturing; plastic_additive, inert_ingredient; Pesticides, and 8 more. Source: EPA CPDat.
Is Fumaric acid used in cosmetics?
Yes, Fumaric acid is also indexed as a cosmetic ingredient under the name Fumaric Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Fumaric acid come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Fumaric acid used outside industrial chemicals?
Fumaric acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.