Fumaric Acid
INCI: FUMARIC ACID
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Fumaric Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1250 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 400 mg/kg bw/day | oral | guinea pig | Chronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 600 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 1500 mg/kg bw/day | oral | rabbit | Subchronic | COSMOS_DB |
| NOAEL | 1500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 2070 mg/kg bw/day | oral | rabbit | Subchronic | COSMOS_DB |
| NOAEL | 2786 mg/kg bw/day | oral | mouse | Special Toxicology Study | COSMOS_DB |
| NOAEL | 2786 mg/kg bw/day | oral | mouse | Special Toxicology Study | COSMOS_DB |
| dose_tested | 1250 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Expert Verdict
Safe pH-buffering and fragrance ingredient with endogenous status. CIR 2009 safety assessment supports safe use. GRAS food status, no EU restrictions, non-irritating, non-sensitizing, negative genotoxicity.
Regulatory Flags
Frequently Asked Questions
Is Fumaric Acid safe in cosmetics?
Safe pH-buffering and fragrance ingredient with endogenous status. CIR 2009 safety assessment supports safe use. GRAS food status, no EU restrictions, non-irritating, non-sensitizing, negative genotoxicity. The EU classifies Fumaric Acid as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Is Fumaric Acid allowed in the EU?
Fumaric Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Fumaric Acid do in cosmetics?
Fumaric Acid functions as: Buffering agent, pH adjuster, fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 110-17-8.
What is the Margin of Safety for Fumaric Acid?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Fumaric Acid?
The NOAEL (No Observed Adverse Effect Level) for Fumaric Acid is 1250 mg/kg bw/day based on a Chronic study via oral route in dog. A total of 10 study endpoints are available. Source: COSMOS_DB.
Is Fumaric Acid classified as hazardous under GHS?
Fumaric Acid carries a GHS signal word of "WARNING". Hazard statements: Causes eye irritation Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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