What is the NOAEL for 3,3'-Thiodipropionic acid?
3,3'-Thiodipropionic acid has 15 NOAEL studies in the database. The lowest reported value is 1 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
3,3'-Thiodipropionic acid
Also known as: Diethyl sulfide 2,2'-dicarboxylic acid, EINECS 203-841-3, NSC 8166, Sulfide, bis(2-carboxyethyl), 4-Thiaheptanedioic acid (+8 more)
CAS 111-17-1
3,3'-Thiodipropionic acid (CAS 111-17-1) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
3,3'-Thiodipropionic acid is classified GHS Danger (H318, H319, H314) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
15
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
19 fields
Name
3,3'-Thiodipropionic acid
CAS Number
111-17-1
DTXSID
DTXSID8044200
Molecular Formula
C6H10O4S
InChI Key
ODJQKYXPKWQWNK-UHFFFAOYSA-N
Monoisotopic Mass
178.02998
Synonyms
Diethyl sulfide 2,2'-dicarboxylic acidEINECS 203-841-3NSC 8166Sulfide, bis(2-carboxyethyl)4-Thiaheptanedioic acidThiahydracrylic acid3,3'-Thiobis(propanoic acid)Thiodihydracrylic acidKyselina 3,3-thiodipropionovaKyselina beta,beta'-thiodipropionovaUNII-3BBK323ED8Bis(2-carboxyethyl) sulfide
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
3 records
Softener and conditionerCatalystAntioxidant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =3.29 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 3BBK323ED8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3BBK323ED8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =3000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1000 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 57 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 565 | mg/kg bw/day | NOAEL | oral | guinea pig | COSMOS_DB |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 1500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =100 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =200 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =300 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 15 of 15 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3,3'-thiodi(propionic acid) | 203-841-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
E388
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E388 — ADI: 0-3 mg/kg bw mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include 3,3'-Thiodipropionic acid?
3,3'-Thiodipropionic acid appears on 2 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is 3,3'-Thiodipropionic acid used in cosmetics?
Yes, 3,3'-Thiodipropionic acid is also indexed as a cosmetic ingredient under the name Thiodipropionic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 3,3'-Thiodipropionic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Does 3,3'-Thiodipropionic acid have different safety status in cosmetics vs industrial chemicals?
3,3'-Thiodipropionic acid is classified GHS Danger (H318, H319, H314) in the chemicals database but is allowed in EU cosmetics.
Is 3,3'-Thiodipropionic acid used outside industrial chemicals?
3,3'-Thiodipropionic acid also appears in cosmetics, pharmaceutical, food safety databases.