Is Thiodipropionic Acid safe in cosmetics?
Thiodipropionic Acid has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
Thiodipropionic Acid
Also known as: Diethyl sulfide 2,2'-dicarboxylic acid, EINECS 203-841-3, NSC 8166, Sulfide, bis(2-carboxyethyl), 4-Thiaheptanedioic acid (+8 more)
INCI: THIODIPROPIONIC ACID (TDPA)
Thiodipropionic Acid (CAS 111-17-1) is a cosmetic cosmetic ingredient functioning as Antioxidant. NOAEL 100 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 111-17-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Thiodipropionic Acid is classified GHS Danger (H318, H319, H314) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antioxidant
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
3-(2-carboxyethylsulfanyl)propanoic acid
InChIKey
ODJQKYXPKWQWNK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR assessed: "Safe for use in cosmetics with qualifications" – formulate to be non-irritating
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Thiodipropionic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Thiodipropionic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 57 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 565 mg/kg bw/day | oral | guinea pig | Subchronic | COSMOS_DB |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Thiodipropionic Acid across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (1)
JECFA Evaluation
THIODIPROPIONIC ACID | 1973 | 0-3 mg/kg bw | NMRS 53/TRS 539-JECFA 17/19 | FAS 5/NMRS 53A-JECFA 17/205
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Catalyst
Softener and conditioner
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Thiodipropionic Acid.
Regulatory Flags
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Thiodipropionic Acid by CAS number or substance name.
Studies
4
Lowest NOAEL
57 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
Known Synonyms
Diethyl sulfide 2,2'-dicarboxylic acid
EINECS 203-841-3
NSC 8166
Sulfide, bis(2-carboxyethyl)
4-Thiaheptanedioic acid
Thiahydracrylic acid
3,3'-Thiobis(propanoic acid)
Thiodihydracrylic acid
Kyselina 3,3-thiodipropionova
Kyselina beta,beta'-thiodipropionova
UNII-3BBK323ED8
Bis(2-carboxyethyl) sulfide
Propanoic acid, 3,3'-thiobis-
Chemical Function
Softener and conditioner
Catalyst
Antioxidant
Regulatory Lists
drinking_water; Europe; manufacturing; plastic_additive
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
E388
ChEMBL ID
CHEMBL1569439
Frequently Asked Questions
Is Thiodipropionic Acid allowed in the EU?
Thiodipropionic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Thiodipropionic Acid do in cosmetics?
Thiodipropionic Acid functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 111-17-1.
What is the NOAEL for Thiodipropionic Acid?
The NOAEL (No Observed Adverse Effect Level) for Thiodipropionic Acid is 57 mg/kg bw/day based on a Developmental study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.
Is Thiodipropionic Acid used outside cosmetics?
Thiodipropionic Acid also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Thiodipropionic Acid have different safety status in cosmetics vs industrial chemicals?
Thiodipropionic Acid is classified GHS Danger (H318, H319, H314) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Thiodipropionic Acid compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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