Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
9 study endpoints found for Thiodipropionic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 565 mg/kg bw/day | oral | guinea pig | Subchronic | COSMOS_DB |
| NOAEL | 57 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 1500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| dose_tested | 1000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 565 mg/kg bw/day | oral | guinea pig | Subchronic | COSMOS_DB |
| dose_tested | 57 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| dose_tested | 1500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
Expert Verdict
Causes serious eye damage/irritation (GHS H318/H319) – avoid eye-area products or ensure adequate dilution; formulate to be non-irritating per CIR qualification
Regulatory Flags
Frequently Asked Questions
Is Thiodipropionic Acid safe in cosmetics?
Causes serious eye damage/irritation (GHS H318/H319) – avoid eye-area products or ensure adequate dilution; formulate to be non-irritating per CIR qualification The EU classifies Thiodipropionic Acid as "permitted". Safety rating: GOOD. 9 toxicological study endpoint(s) are available in our database.
Is Thiodipropionic Acid allowed in the EU?
Thiodipropionic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Thiodipropionic Acid do in cosmetics?
Thiodipropionic Acid functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 111-17-1.
What is the Margin of Safety for Thiodipropionic Acid?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Thiodipropionic Acid?
The NOAEL (No Observed Adverse Effect Level) for Thiodipropionic Acid is 1000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 9 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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