What is the NOAEL for 2,6,6-Trimethyl-2-cyclohexene-1,4-dione?
2,6,6-Trimethyl-2-cyclohexene-1,4-dione has 4 NOAEL studies in the database. The lowest reported value is 72WY3KLB5R UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2,6,6-Trimethyl-2-cyclohexene-1,4-dione
Also known as: keto-Isophorone, 6-Oxoisophorone, 4-Oxo-alpha-isophorone, UNII-72WY3KLB5R, 2-Cyclohexene-1,4-dione, 2,6,6-trimethyl- (+7 more)
CAS 1125-21-9
2,6,6-Trimethyl-2-cyclohexene-1,4-dione (CAS 1125-21-9) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Trimethyl-2-cyclohexene-1,4-dione →
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
2,6,6-Trimethyl-2-cyclohexene-1,4-dione
CAS Number
1125-21-9
DTXSID
DTXSID9021685
Molecular Formula
C9H12O2
InChI Key
AYJXHIDNNLJQDT-UHFFFAOYSA-N
Monoisotopic Mass
152.08373
Synonyms
keto-Isophorone6-Oxoisophorone4-Oxo-alpha-isophoroneUNII-72WY3KLB5R2-Cyclohexene-1,4-dione, 2,6,6-trimethyl-KetoisophoroneEINECS 214-406-2FEMA No. 34214-OxoisophoroneOxopholoneOxophorone3,5,5-Trimethyl-2-cyclohexene-1,4-dione
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 72WY3KLB5R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 72WY3KLB5R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 72WY3KLB5R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 72WY3KLB5R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,6,6-trimethylcyclohex-2-ene-1,4-dione | 214-406-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2,6,6-Trimethyl-2-cyclohexene-1,4-dione?
2,6,6-Trimethyl-2-cyclohexene-1,4-dione appears on 3 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is 2,6,6-Trimethyl-2-cyclohexene-1,4-dione used in cosmetics?
Yes, 2,6,6-Trimethyl-2-cyclohexene-1,4-dione is also indexed as a cosmetic ingredient under the name Trimethyl-2-cyclohexene-1,4-dione. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,6,6-Trimethyl-2-cyclohexene-1,4-dione come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 2,6,6-Trimethyl-2-cyclohexene-1,4-dione used outside industrial chemicals?
2,6,6-Trimethyl-2-cyclohexene-1,4-dione also appears in cosmetics, cannabis databases.