Trimethyl-2-cyclohexene-1,4-dione

INCI: TRIMETHYL-2-CYCLOHEXENE-1,4-DIONE (ALSO KNOWN AS KETOISOPHORONE)

CAS Number
1125-21-9
Function
Fragrance ingredient; also used as flavoring agent (JECFA \#1857)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted in cosmetics and as food additive (EAFUS listed)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

None significant; RIFM environmental assessment shows non-persistent, non-bioaccumulative

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Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Trimethyl-2-cyclohexene-1,4-dione safe in cosmetics?

None significant; RIFM environmental assessment shows non-persistent, non-bioaccumulative The EU classifies Trimethyl-2-cyclohexene-1,4-dione as "permitted". Safety rating: GOOD.

Is Trimethyl-2-cyclohexene-1,4-dione allowed in the EU?

Trimethyl-2-cyclohexene-1,4-dione EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Trimethyl-2-cyclohexene-1,4-dione do in cosmetics?

Trimethyl-2-cyclohexene-1,4-dione functions as: Fragrance ingredient; also used as flavoring agent (JECFA \#1857). It is classified as a cosmetic ingredient in our database. CAS number: 1125-21-9.

What is the Margin of Safety for Trimethyl-2-cyclohexene-1,4-dione?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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