NOAEL Data REACH Registered Cosmetic Ingredient

2-Ethylhexanal

Also known as: Hexanal, 2-ethyl-, Caproaldehyde, α-ethyl-, 4-01-00-03345, BRN 1700556, Butyl ethyl acetaldehyde (+6 more)

CAS 123-05-7

2-Ethylhexanal (CAS 123-05-7) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Ethylhexanal (2-Ethylhexanal) →

Cross-Vertical Regulatory Divergence

2-Ethylhexanal is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H315, H317, H319, H361).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 17 fields

Name

2-Ethylhexanal

CAS Number

123-05-7

DTXSID

DTXSID9025291

Molecular Formula

C8H16O

InChI Key

LGYNIFWIKSEESD-UHFFFAOYSA-N

Monoisotopic Mass

128.120115

Synonyms

Hexanal, 2-ethyl-Caproaldehyde, α-ethyl-4-01-00-03345BRN 1700556Butyl ethyl acetaldehydeEINECS 204-596-5Octyl aldehyde2-ethylhexan-1-alalpha-ethylcaproaldehydealpha-ethylhexanalbeta-propyl-alpha-ethylacrolein

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The substance is irritating to the eyes and skin. The vapour is irritating to the respiratory tract.
Long-term Effects	Repeated or prolonged contact with skin may cause dermatitis.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records

FragranceFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records

List	Keyword	Source
artificial_sweat; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
artificial_sweat; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 13 of 13 studies

Value	Unit	Endpoint	Route	Species	Source
=1.53	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
SEN8S34O6U	UNII	FDA UNII substance identifier	-	-	openFDA substances
SEN8S34O6U	UNII	FDA UNII substance identifier	-	-	openFDA substances
SEN8S34O6U	UNII	FDA UNII substance identifier	-	-	openFDA substances
SEN8S34O6U	UNII	FDA UNII substance identifier	-	-	openFDA substances
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
1350	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
>4.1	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
>6.83	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
-	unitless	Model Score	-	-	NTP_ICE_endocrine
=50	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=50	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
3	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization

Showing 13 of 13 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	2-ethylhexanal	204-596-5	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1558074

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for 2-Ethylhexanal?

2-Ethylhexanal has 13 NOAEL studies in the database. The lowest reported value is 1.53 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include 2-Ethylhexanal?

2-Ethylhexanal appears on 4 regulatory/inventory lists including artificial_sweat; detected; emissions; Europe; Toys and children's products, active_ingredient; Europe; Pesticides, IFRA Transparency, and 1 more. Source: EPA CPDat.

Is 2-Ethylhexanal used in cosmetics?

Yes, 2-Ethylhexanal is also indexed as a cosmetic ingredient under the name Ethylhexanal (2-Ethylhexanal). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Ethylhexanal come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Ethylhexanal have different safety status in cosmetics vs industrial chemicals?

2-Ethylhexanal is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H315, H317, H319, H361).

Is 2-Ethylhexanal used outside industrial chemicals?

2-Ethylhexanal also appears in cosmetics, pharmaceutical, cannabis databases.