Ethylhexanal (2-Ethylhexanal)
INCI: ETHYLHEXANAL
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Ethylhexanal (2-Ethylhexanal). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 0.54 2100 | 1991 | rat | inhalation | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Skin sensitization is the primary concern. ECHA REACH dossier identifies developmental toxicity NOAEL of 100 mg/kg/day. Aldehyde functional group can form Schiff bases with skin proteins via haptenation mechanism. Must comply with IFRA quantitative limits. If formulation exceeds 0.001% in leave-on products, allergen disclosure should be considered.
Regulatory Flags
Frequently Asked Questions
Is Ethylhexanal (2-Ethylhexanal) safe in cosmetics?
Skin sensitization is the primary concern. ECHA REACH dossier identifies developmental toxicity NOAEL of 100 mg/kg/day. Aldehyde functional group can form Schiff bases with skin proteins via haptenation mechanism. Must comply with IFRA quantitative limits. If formulation exceeds 0.001% in leave-on products, allergen disclosure should be considered. The EU classifies Ethylhexanal (2-Ethylhexanal) as "prohibited". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.
Is Ethylhexanal (2-Ethylhexanal) allowed in the EU?
Ethylhexanal (2-Ethylhexanal) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethylhexanal (2-Ethylhexanal) do in cosmetics?
Ethylhexanal (2-Ethylhexanal) functions as: Fragrance ingredient, denaturant. It is classified as a cosmetic ingredient in our database. CAS number: 123-05-7.
What is the Margin of Safety for Ethylhexanal (2-Ethylhexanal)?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Ethylhexanal (2-Ethylhexanal)?
The NOAEL (No Observed Adverse Effect Level) for Ethylhexanal (2-Ethylhexanal) is 0.54 2100 based on a inhalation study via 1991 route in rat. Source: REACH.
Compliance Tools
Check Ethylhexanal (2-Ethylhexanal) compliance across multiple jurisdictions:
Related Ingredients
Is Ethylhexanal (2-Ethylhexanal) in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Ethylhexanal (2-Ethylhexanal) in your formulation.