What is the NOAEL for Glycyrrhizin?
Glycyrrhizin has 7 NOAEL studies in the database. The lowest reported value is 6FO62043WK UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Glycyrrhizin
Also known as: alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, EC No.: 215-785-7, EC No.: 917-414-0, 4-18-00-05156, BRN 0077922 (+14 more)
CAS 1405-86-3
Glycyrrhizin (CAS 1405-86-3) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Glycyrrhizin
CAS Number
1405-86-3
DTXSID
DTXSID8047006
Molecular Formula
C42H62O16
InChI Key
LPLVUJXQOOQHMX-QWBHMCJMSA-N
Monoisotopic Mass
822.403786
Synonyms
alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-EC No.: 215-785-7EC No.: 917-414-04-18-00-05156BRN 0077922EINECS 215-785-7alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl-2-O-beta-D-glucopyranuron osyl-18-beta-Glycyrrhizic acidGlycyrrizinUNII-6FO62043WK(3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosiduronic acidbeta-Glycyrrhizin
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
HumectantSoftener and conditionerFlavouring and nutrientFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 6FO62043WK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6FO62043WK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6FO62043WK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6FO62043WK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.05 | fraction | Fu | - | Rat | NTP_ICE_adme_parameters |
| =2 | mg/kg bw/day | NOAEL | oral | Human | ToxValDB_WHO_JECFA_Tox_Studies |
| =2000 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB_ECOTOX |
Showing 7 of 7 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
GLYCYRRHIZIN
ChEMBL Phase
2
Adverse Events
102
Bioactivity
13
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: 100 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Glycyrrhizin?
Glycyrrhizin appears on 2 regulatory/inventory lists including Europe, Canada; pharmaceutical. Source: EPA CPDat.
Is Glycyrrhizin used in cosmetics?
Yes, Glycyrrhizin is also indexed as a cosmetic ingredient under the name Glycyrrhizic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Glycyrrhizin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Glycyrrhizin used outside industrial chemicals?
Glycyrrhizin also appears in cosmetics, pharmaceutical, food safety, cannabis databases.