Is Glycyrrhizic Acid safe in cosmetics?
Glycyrrhizic Acid has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Good
Cosmetic Ingredient
Glycyrrhizic Acid
Also known as: alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, EC No.: 215-785-7, EC No.: 917-414-0, 4-18-00-05156, BRN 0077922 (+14 more)
INCI: GLYCYRRHIZIC ACID
Glycyrrhizic Acid (CAS 1405-86-3) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent; flavoring agent. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1405-86-3 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent; flavoring agent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
InChIKey
LPLVUJXQOOQHMX-QWBHMCJMSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted - CIR assessed as safe in present practices of use and concentration
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Glycyrrhizic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Regulatory (1)
JECFA Evaluation
GLYCYRRHIZINIC ACID | 2005 | The Committee concluded that the critical effect of glycyrrhizinic acid is pseudohyperaldosteronism, which, when sustained, can lead to elevated blood pressure.The Committee concluded that the safety evaluation of glycyrrizinic acid should be based on the data from humans. As the available data from clinical studies did not allow the Committee to adequately characteriz
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Glycyrrhizic Acid.
Known Synonyms
alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-
EC No.: 215-785-7
EC No.: 917-414-0
4-18-00-05156
BRN 0077922
EINECS 215-785-7
alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl-2-O-beta-D-glucopyranuron osyl-
18-beta-Glycyrrhizic acid
Glycyrrizin
UNII-6FO62043WK
(3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid
beta-Glycyrrhizin
18beta-Glycyrrhizic acid
Neo-Umor
(3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl-2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid
glyzyrrhizin
.alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-
(3β)-30-hydroxy-11,30-dioxoolean-12-en-3-yl 2-O-β-D-glucopyranuronosyl-α-D-glucopyranosiduronic acid
215-785-7
Chemical Function
Humectant
Softener and conditioner
Flavouring and nutrient
Fragrance
Regulatory Lists
Europe
Canada; pharmaceutical
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
GLYCYRRHIZIN
ChEMBL ID
CHEMBL441687
Max Phase
2
Adverse Event Associations
102
Frequently Asked Questions
Is Glycyrrhizic Acid allowed in the EU?
Glycyrrhizic Acid EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Glycyrrhizic Acid do in cosmetics?
Glycyrrhizic Acid functions as: Skin conditioning agent; flavoring agent. It is classified as a cosmetic ingredient in our database. CAS number: 1405-86-3.
Is Glycyrrhizic Acid used outside cosmetics?
Glycyrrhizic Acid also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Glycyrrhizic Acid compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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Chemical family
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