What is the NOAEL for Diphenhydramine hydrochloride?
Diphenhydramine hydrochloride has 37 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP ICE adme parameters.
NOAEL Data
Cosmetic Ingredient
Diphenhydramine hydrochloride
Also known as: Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride, Difenhydramine hydrochloride, Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride (1:1), Ambenyl, Bendylate (+14 more)
CAS 147-24-0
Diphenhydramine hydrochloride (CAS 147-24-0) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
Cross-Vertical Regulatory Divergence
Diphenhydramine hydrochloride is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H361, H362, H370, H372, H373).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
37
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
24 fields
Name
Diphenhydramine hydrochloride
CAS Number
147-24-0
Molecular Formula
C17H21NO.ClH
InChI Key
PCHPORCSPXIHLZ-UHFFFAOYSA-N
Monoisotopic Mass
291.138992
Synonyms
Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochlorideDifenhydramine hydrochlorideEthanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride (1:1)AmbenylBendylateBenzantin hydrochlorideBenzhydrol, beta-dimethylaminoethyl ether hydrochlorideCarphenamineCarphenexCathejellDimedrolumbeta-Dimethylaminoethyl benzhydryl ether hydrochloride
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
13 records
Softener and conditionerPharmaceutical
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 37 of 37 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| TC2D6JAD40 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.4131 | fraction | Fu | - | Human | NTP ICE adme parameters |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 1.552e+4 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| =500 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =7 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =7 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =13 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =13 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =15.7 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =15.7 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =21 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB ToxRefDB |
| =21 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =93.8 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB ToxRefDB |
| =93.8 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =31.3 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB ToxRefDB |
| =31.3 | mg/kg bw/day | LOAEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =46 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB ToxRefDB |
| =46 | mg/kg bw/day | LOAEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =47 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB ToxRefDB |
| =47 | mg/kg bw/day | LOAEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| >0 | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =7.8 | mg/kg bw/day | NEL | oral | Rat | ToxValDB ToxRefDB |
| =7.8 | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =47 | mg/kg bw/day | NEL | oral | Mouse | ToxValDB ToxRefDB |
| =47 | mg/kg bw/day | NEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =0.6 | mg/L | NOEC | environmental | Rat | ToxValDB ECOTOX |
| =2 | mg/L | NOEC | environmental | Rat | ToxValDB ECOTOX |
| =5 | mg/L | NOEC | environmental | Rat | ToxValDB ECOTOX |
| =6 | mg/L | NOEC | environmental | Rat | ToxValDB ECOTOX |
| =10 | mg/L | NOEC | environmental | Rat | ToxValDB ECOTOX |
| =20 | mg/L | NOEC | environmental | Rat | ToxValDB ECOTOX |
| 1 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
| 313 | ppm | Top dose | Dosed feed | Mouse | NTP ICE cancer |
| 625 | ppm | Top dose | Dosed feed | Rat | NTP ICE cancer |
Showing 37 of 37 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
DIPHENHYDRAMINE HYDROCHLORIDE
ChEMBL Phase
4
Adverse Events
9
Bioactivity
3
Frequently Asked Questions
What regulatory lists include Diphenhydramine hydrochloride?
Diphenhydramine hydrochloride appears on 3 regulatory/inventory lists including detected; MN Chemical Screening; surface_water, active_ingredient; Australia, Canada; Personal care; Substances in PCP - Canada (4/2014). Source: EPA CPDat.
Is Diphenhydramine hydrochloride used in cosmetics?
Yes, Diphenhydramine hydrochloride is also indexed as a cosmetic ingredient under the name Diphenhydramine HCl. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diphenhydramine hydrochloride come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Diphenhydramine hydrochloride have different safety status in cosmetics vs industrial chemicals?
Diphenhydramine hydrochloride is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H361, H362, H370, H372, H373).
Is Diphenhydramine hydrochloride used outside industrial chemicals?
Diphenhydramine hydrochloride also appears in cosmetics, pharmaceutical databases.