What is the NOAEL for Tert-Butylhydroquinone?
Tert-Butylhydroquinone has 79 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Tert-Butylhydroquinone
Also known as: t-Butylhydroquinone, 1,4-Benzenediol, 2-(1,1-dimethylethyl)-, tBHQ, 1,4-Benzenediol (1,1-dimethylethyl)-, BRN 0637923 (+11 more)
CAS 1948-33-0
Tert-Butylhydroquinone (CAS 1948-33-0) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for TBHQ (tert-Butylhydroquinone) →
SOURCE
NOAEL studies
NOAEL studies
79
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
Tert-Butylhydroquinone
CAS Number
1948-33-0
Molecular Formula
C10H14O2
InChI Key
BGNXCDMCOKJUMV-UHFFFAOYSA-N
Monoisotopic Mass
166.09938
Synonyms
t-Butylhydroquinone1,4-Benzenediol, 2-(1,1-dimethylethyl)-tBHQ1,4-Benzenediol (1,1-dimethylethyl)-BRN 0637923EINECS 217-752-2UNII-C12674942Btert-ButylhydrochinoneTertiary butylhydroquinone2-Tertiary-butylhydroquinone2-t-Butyl-1,4-benzenediol2-tert-Butyl(1,4)hydroquinone
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
12 records
AntioxidantDeodorizerFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 79 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 29.21 | uM | AC50 | - | - | NTP ICE endocrine |
| 48.25 | uM | AC50 | - | - | NTP ICE endocrine |
| 41.12 | uM | ACC | - | - | NTP ICE endocrine |
| 53.18 | uM | ACC | - | - | NTP ICE endocrine |
| range:0-0.20.2 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| <=0.7 | mg/kg | ADI | oral | Human | WHO/JECFA |
| <=0.7 | mg/kg bw/day | ADI | - | Consumers | EFSA |
| range:0-0.70.7 | mg/kg bw/day | ADI | - | - | WHO/JECFA |
| =19.7 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| C12674942B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =50 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =50 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =60 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =60 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =200 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =200 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| >240 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| >240 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =400 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =400 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =600 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB ToxRefDB |
| =600 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =700 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB ToxRefDB |
| =700 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =750 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =750 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =800 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =800 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =1000 | mg/kg bw/day | LEL | oral | Rat | ToxValDB ToxRefDB |
| =1000 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =1950 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB ToxRefDB |
| =1950 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =2200 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB ToxRefDB |
| =2200 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =200 | mg/kg bw/day | LOAEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =240 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB ToxRefDB |
| =2 | % | LOEL | oral | Rat | ToxValDB ECOTOX |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.00291 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.0164 | unitless | Model Score | - | - | NTP ICE endocrine |
| >0 | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =300 | mg/kg bw/day | NEL | oral | Mouse | ToxValDB ToxRefDB |
| =300 | mg/kg bw/day | NEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =400 | mg/kg bw/day | NEL | oral | Rat | ToxValDB ToxRefDB |
| =500 | mg/kg bw/day | NEL | oral | Rat | ToxValDB ToxRefDB |
| =500 | mg/kg bw/day | NEL | oral | rat (fischer; Fischer 344) | EPA ToxRefDB v3 |
| =880 | mg/kg bw/day | NEL | oral | Mouse | ToxValDB ToxRefDB |
| =880 | mg/kg bw/day | NEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =1100 | mg/kg bw/day | NEL | oral | Mouse | ToxValDB ToxRefDB |
| =1100 | mg/kg bw/day | NEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
Showing 50 of 79 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-tert-butylhydroquinone | 217-752-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
E319
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
5
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
E319 — ADI: 0.7 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Tert-Butylhydroquinone?
Tert-Butylhydroquinone appears on 3 regulatory/inventory lists including IFRA Transparency, Canada; pharmaceutical, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Tert-Butylhydroquinone used in cosmetics?
Yes, Tert-Butylhydroquinone is also indexed as a cosmetic ingredient under the name TBHQ (tert-Butylhydroquinone). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Tert-Butylhydroquinone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Tert-Butylhydroquinone used outside industrial chemicals?
Tert-Butylhydroquinone also appears in cosmetics, pharmaceutical, food safety, cannabis databases.