Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for TBHQ (tert-Butylhydroquinone). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 125 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Reproductive-developmental | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 277 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| NOAEL | 326 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 600 mg/kg bw/day | oral | hamster | Subchronic | COSMOS_DB |
Expert Verdict
Must not exceed 0.1% in cosmetics (CIR limit); potential skin depigmentation at higher levels; not approved in Japan for food use; Health Canada also caps at 0.1%
Regulatory Flags
Frequently Asked Questions
Is TBHQ (tert-Butylhydroquinone) safe in cosmetics?
Must not exceed 0.1% in cosmetics (CIR limit); potential skin depigmentation at higher levels; not approved in Japan for food use; Health Canada also caps at 0.1% The EU classifies TBHQ (tert-Butylhydroquinone) as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is TBHQ (tert-Butylhydroquinone) allowed in the EU?
TBHQ (tert-Butylhydroquinone) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does TBHQ (tert-Butylhydroquinone) do in cosmetics?
TBHQ (tert-Butylhydroquinone) functions as: Antioxidant, Masking, Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 1948-33-0.
What is the Margin of Safety for TBHQ (tert-Butylhydroquinone)?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for TBHQ (tert-Butylhydroquinone)?
The NOAEL (No Observed Adverse Effect Level) for TBHQ (tert-Butylhydroquinone) is 125 mg/kg bw/day based on a Chronic study via oral route in dog. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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