NOAEL Data REACH Registered Cosmetic Ingredient

Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane

Also known as: BRN 4308125, EINECS 219-784-2, 3-(2,3-Epoxypropoxy)propyltrimethoxysilane, (3-(Glycidyloxy)propyl)trimethoxysilane, Silan A 187 (+6 more)

CAS 2530-83-8

Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane (CAS 2530-83-8) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Glycidoxypropyl Trimethoxysilane →

Cross-Vertical Regulatory Divergence

Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane is prohibited in EU cosmetics but has active industrial GHS classifications (H318, H341, H412, H315, H319, H335, H402).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 17 fields

Name

Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane

CAS Number

2530-83-8

DTXSID

DTXSID5027489

Molecular Formula

C9H20O5Si

InChI Key

BPSIOYPQMFLKFR-UHFFFAOYSA-N

Monoisotopic Mass

236.108

Synonyms

BRN 4308125EINECS 219-784-23-(2,3-Epoxypropoxy)propyltrimethoxysilane(3-(Glycidyloxy)propyl)trimethoxysilaneSilan A 187Silane-y-4087Silicone A-187Silicone KBM 403((3-(Trimethoxysilyl)propoxy)methyl)oxiraneUnion carbide a-187UNII-5K9X9X899R

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

Softener and conditionerAdhesion/cohesion promoterViscosity modifierChemical reaction regulatorThickening agentHardenerWetting agent (non-aqueous)

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records

List	Keyword	Source
CEDI	FDA	United States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 18 of 18 studies

Value	Unit	Endpoint	Route	Species	Source
=70.5	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
=260	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
2	unitless	Draize rabbit irritation score	Ocular	Rabbit	NTP_ICE_eye_irritation
5K9X9X899R	UNII	FDA UNII substance identifier	-	-	openFDA substances
5K9X9X899R	UNII	FDA UNII substance identifier	-	-	openFDA substances
5K9X9X899R	UNII	FDA UNII substance identifier	-	-	openFDA substances
5K9X9X899R	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.11	%/sec	Intensity	Ocular	-	NTP_ICE_eye_irritation
=2000	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ECHA_IUCLID
-	s	Lag time	Ocular	-	NTP_ICE_eye_irritation
=225	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
>11.1	mg/kg bw/day	NOAEL	dermal	Mouse	ToxValDB_ECHA_IUCLID
>=400	mg/kg bw/day	NOAEL	oral	Rabbit	ToxValDB_ECHA_IUCLID
=500	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
>=1000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
>1000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_HESS
=1500	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
20.2	%	Plateau level	Ocular	-	NTP_ICE_eye_irritation

Showing 18 of 18 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	[3-(2,3-epoxypropoxy)propyl]trimethoxysilane	219-784-2	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL2140162

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane?

Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane has 18 NOAEL studies in the database. The lowest reported value is 2 unitless via Ocular in Rabbit. Source: NTP_ICE_eye_irritation.

What regulatory lists include Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane?

Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane appears on 1 regulatory/inventory list including CEDI. Source: EPA CPDat.

Is Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane used in cosmetics?

Yes, Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane is also indexed as a cosmetic ingredient under the name Glycidoxypropyl Trimethoxysilane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane have different safety status in cosmetics vs industrial chemicals?

Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane is prohibited in EU cosmetics but has active industrial GHS classifications (H318, H341, H412, H315, H319, H335, H402).

Is Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane used outside industrial chemicals?

Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane also appears in cosmetics, pharmaceutical, cannabis databases.