What is the NOAEL for Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane?
Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane has 15 NOAEL studies in the database. The lowest reported value is 0 s via Ocular. Source: NTP ICE eye irritation.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane
Also known as: BRN 4308125, EINECS 219-784-2, 3-(2,3-Epoxypropoxy)propyltrimethoxysilane, (3-(Glycidyloxy)propyl)trimethoxysilane, Silan A 187 (+6 more)
CAS 2530-83-8
Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane (CAS 2530-83-8) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Glycidoxypropyl Trimethoxysilane →
Cross-Vertical Regulatory Divergence
Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane is prohibited in EU cosmetics but has active industrial GHS classifications (H318, H341, H412, H315, H319, H335, H402).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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NOAEL studies
NOAEL studies
15
SOURCE
Chemical inventory jurisdictions
Regulatory lists
1
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane
CAS Number
2530-83-8
Molecular Formula
C9H20O5Si
InChI Key
BPSIOYPQMFLKFR-UHFFFAOYSA-N
Monoisotopic Mass
236.108
Synonyms
BRN 4308125EINECS 219-784-23-(2,3-Epoxypropoxy)propyltrimethoxysilane(3-(Glycidyloxy)propyl)trimethoxysilaneSilan A 187Silane-y-4087Silicone A-187Silicone KBM 403((3-(Trimethoxysilyl)propoxy)methyl)oxiraneUnion carbide a-187UNII-5K9X9X899R
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Softener and conditionerAdhesion/cohesion promoterViscosity modifierChemical reaction regulatorThickening agentHardenerWetting agent (non-aqueous)
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| CEDI | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =70.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| =260 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 2 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP ICE eye irritation |
| 5K9X9X899R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.11 | %/sec | Intensity | Ocular | - | NTP ICE eye irritation |
| =2000 | mg/kg bw/day | LEL | oral | Rat | ECHA |
| 0 | s | Lag time | Ocular | - | NTP ICE eye irritation |
| =225 | mg/m3 | NOAEC | inhalation | Rat | ECHA |
| >11.1 | mg/kg bw/day | NOAEL | dermal | Mouse | ECHA |
| >=400 | mg/kg bw/day | NOAEL | oral | Rabbit | ECHA |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| >=1000 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| >1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB HESS |
| =1500 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| 20.2 | % | Plateau level | Ocular | - | NTP ICE eye irritation |
Showing 15 of 15 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | [3-(2,3-epoxypropoxy)propyl]trimethoxysilane | 219-784-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL2140162
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane?
Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane appears on 1 regulatory/inventory list including CEDI. Source: EPA CPDat.
Is Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane used in cosmetics?
Yes, Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane is also indexed as a cosmetic ingredient under the name Glycidoxypropyl Trimethoxysilane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane have different safety status in cosmetics vs industrial chemicals?
Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane is prohibited in EU cosmetics but has active industrial GHS classifications (H318, H341, H412, H315, H319, H335, H402).
Is Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane used outside industrial chemicals?
Trimethoxy[3-(oxiran-2-ylmethoxy)propyl]silane also appears in cosmetics, pharmaceutical, cannabis databases.