What is the NOAEL for Citrulline?
Citrulline has 4 NOAEL studies in the database. The lowest reported value is 29VT07BGDA UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Citrulline
Also known as: L-Ornithine, N5-(aminocarbonyl)-, N5-(Aminocarbonyl)-L-ornithine, Ornithine, N5-carbamoyl-, L-, α-Amino-δ-ureidovaleric acid, δ-Ureidonorvaline (+6 more)
CAS 372-75-8
Citrulline (CAS 372-75-8) is a chemical substance. Key regulatory status: 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
Citrulline
CAS Number
372-75-8
DTXSID
DTXSID80883373
Molecular Formula
C6H13N3O3
InChI Key
RHGKLRLOHDJJDR-BYPYZUCNSA-N
Monoisotopic Mass
175.095691
Synonyms
L-Ornithine, N5-(aminocarbonyl)-N5-(Aminocarbonyl)-L-ornithineOrnithine, N5-carbamoyl-, L-α-Amino-δ-ureidovaleric acidδ-UreidonorvalineL-(+)-CitrullineL-CitrullineNδ-CarbamylornithineN5-Carbamoyl-L-ornithineCitNSC 27425
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
Softener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 29VT07BGDA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 29VT07BGDA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 29VT07BGDA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 29VT07BGDA | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
L-CITRULLINE
ChEMBL Phase
3
Adverse Events
3
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include Citrulline?
Citrulline appears on 3 regulatory/inventory lists including active_ingredient; animal_products; Europe; pharmaceutical; residue, Canada; pharmaceutical, Canada; Personal care; Substances in PCP - Canada (4/2014). Source: EPA CPDat.
Is Citrulline used in cosmetics?
Yes, Citrulline is also indexed as a cosmetic ingredient under the name CITRULLINE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Citrulline come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Citrulline used outside industrial chemicals?
Citrulline also appears in cosmetics, pharmaceutical, food safety databases.