What is the NOAEL for Sulindac?
Sulindac has 8 NOAEL studies in the database. The lowest reported value is developmental, female listing type. Source: California Proposition 65.
NOAEL Data
Prop 65
Cosmetic Ingredient
Sulindac
Also known as: 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-, (Z)-, BRN 2951842, EINECS 253-819-2, (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid, Sulindacum (+6 more)
CAS 38194-50-2
Sulindac (CAS 38194-50-2) is a chemical substance; key hazard signal: developmental, female. Key regulatory status: California Proposition 65, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, CA Prop 65.
Cross-Vertical Regulatory Divergence
Sulindac is classified GHS Danger (H301, H317, H319, H334, H360, H361, H373) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
Sulindac
CAS Number
38194-50-2
DTXSID
DTXSID4023624
Molecular Formula
C20H17FO3S
InChI Key
MLKXDPUZXIRXEP-MFOYZWKCSA-N
Monoisotopic Mass
356.088244
Synonyms
1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-, (Z)-BRN 2951842EINECS 253-819-2(Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acidSulindacumUNII-184SNS8VUHcis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidenyl)indene-3-acetic acidEINECS 256-402-3(Z)-(1)-5-Fluoro-2-methyl-1-((4-(methylsulphinyl)phenyl)methylene)-1H-indene-3-acetic acidcis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acidcis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid
California Proposition 65
California OEHHA listing status and toxicity category.
SOURCE
California OEHHA Proposition 65 List
1 records
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | developmental, female | No | Yes | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Antioxidant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| FRdevelopmental, female | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| FRdevelopmental, female | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| FRdevelopmental, female | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| FRdevelopmental, female | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| 184SNS8VUH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 184SNS8VUH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 184SNS8VUH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 184SNS8VUH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 8 of 8 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
SULINDAC
ChEMBL Phase
4
Adverse Events
170
Bioactivity
19
Frequently Asked Questions
What regulatory lists include Sulindac?
Sulindac appears on 5 regulatory/inventory lists including pharmaceutical, OEHHA Proposition 65 (3/2019), Canada; pharmaceutical, and 2 more. Source: EPA CPDat.
Is Sulindac on the California Proposition 65 list?
Yes, Sulindac is listed under California Proposition 65 for developmental, female. Source: California OEHHA Proposition 65.
Is Sulindac used in cosmetics?
Yes, Sulindac is also indexed as a cosmetic ingredient under the name Sulindac. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Sulindac come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, California Proposition 65, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Sulindac have different safety status in cosmetics vs industrial chemicals?
Sulindac is classified GHS Danger (H301, H317, H319, H334, H360, H361, H373) in the chemicals database but is allowed in EU cosmetics.
Is Sulindac used outside industrial chemicals?
Sulindac also appears in cosmetics, pharmaceutical databases.