Is Sulindac safe in cosmetics?
Sulindac has a safety rating of "MODERATE" in our database. EU status: permitted. US status: restricted.
Moderate
Cosmetic Ingredient
Sulindac
INCI: SULINDAC
Sulindac (CAS 38194-50-2) is a cosmetic cosmetic ingredient functioning as Antioxidant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 38194-50-2 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid
InChIKey
MLKXDPUZXIRXEP-MFOYZWKCSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
FDA-approved as an oral NSAID drug; cosmetic topical use not specifically restricted but primarily a pharmaceutical ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sulindac.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Regulatory List Membership (1)
California Proposition 65 (OEHHA)
Expert Verdict
Expert safety assessment and concern-level summary for Sulindac.
Regulatory Flags
prop65
Chemical Function
Antioxidant
Regulatory Lists
pharmaceutical
OEHHA Proposition 65 (3/2019)
Canada; pharmaceutical
Canada; pharmaceutical
OEHHA Proposition 65 (1/2023)
Canada; consumer_product; Substances in Products - Canada (4/2014)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SULINDAC
ChEMBL ID
CHEMBL15770
Max Phase
4
Adverse Event Associations
170
Frequently Asked Questions
Is Sulindac allowed in the EU?
Sulindac EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sulindac do in cosmetics?
Sulindac functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 38194-50-2.
Is Sulindac used outside cosmetics?
Sulindac also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Sulindac compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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