NOAEL Data Cosmetic Ingredient

Genistein

Also known as: 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone, Isoflavone, 4',5,7-trihydroxy-, 4',5,7-Trihydroxyisoflavone, GeniVida (+14 more)

CAS 446-72-0

Genistein (CAS 446-72-0) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.

View cosmetic safety profile for Soy Isoflavones →

SOURCE noael studies public
NOAEL studies
100
SOURCE chemical inventory jurisdictions
Regulatory lists
1
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields
Name
Genistein
CAS Number
446-72-0
DTXSID
DTXSID5022308
Molecular Formula
C15H10O5
InChI Key
TZBJGXHYKVUXJN-UHFFFAOYSA-N
Monoisotopic Mass
270.052823
Synonyms
4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyroneIsoflavone, 4',5,7-trihydroxy-4',5,7-TrihydroxyisoflavoneGeniVidaGenistin aglyconeSIPI 807-1Climagen FC.I. 75610FW 635I-25-18-04-00594BRN 0263823

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 1 records
Softener and conditioner

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records
ListKeywordSource
Canada; pharmaceuticalDrugBankDrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
4mg/kg bw/day-oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
4mg/kg bw/day--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=5---ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
7.4mg/kg bw-oralhumanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
7.4mg/kg bw-oralhumanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
7.4mg/kg bw-oralhumanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
15mg/kg bw-oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
20----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
20----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
20----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
20----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
20----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
25%-oralhumanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
25%-oralhumanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
25%-oralhumanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=35mg/kg--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=35mg/kg--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
40mg/kg/day---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
40mg/kg/day---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
40mg/kg/day--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
40mg/kg/day--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=100%-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
100ppm--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
119----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1250ppm-oral-UnifiedCodex:SCCS_SHADOW:beta.noael_studies
0.33676788105873uMAC50--NTP_ICE_endocrine
3.7nMAC50/EC50/IC50--NTP_ICE_endocrine
162.2nMAC50/EC50/IC50--NTP_ICE_endocrine
239.9nMAC50/EC50/IC50--NTP_ICE_endocrine
84500nMAC50/EC50/IC50--NTP_ICE_endocrine
100000nMAC50/EC50/IC50--NTP_ICE_endocrine
140000nMAC50/EC50/IC50--NTP_ICE_endocrine
155000nMAC50/EC50/IC50--NTP_ICE_endocrine
270000nMAC50/EC50/IC50--NTP_ICE_endocrine
1300000nMAC50/EC50/IC50--NTP_ICE_endocrine
0.0615586769783145uMACC--NTP_ICE_endocrine
18.69uL/min/10^6 cellsClint-HumanNTP_ICE_adme_parameters
68uL/min/10^6 cellsClint-RatNTP_ICE_adme_parameters
271nMEC50--NTP_ICE_endocrine
DH2M523P0HUNIIFDA UNII substance identifier--openFDA substances
DH2M523P0HUNIIFDA UNII substance identifier--openFDA substances
DH2M523P0HUNIIFDA UNII substance identifier--openFDA substances
DH2M523P0HUNIIFDA UNII substance identifier--openFDA substances
0.0085fractionFu-RatNTP_ICE_adme_parameters
0.02426fractionFu-HumanNTP_ICE_adme_parameters
=0.00027024mgLELinjectionMouseToxValDB_Uterotrophic_Hershberger_DB
=0.0025mg/kg bw/dayLELinjectionRatToxValDB_Uterotrophic_Hershberger_DB
=0.02mg/kg bw/dayLELinjectionRatToxValDB_Uterotrophic_Hershberger_DB
=0.4mgLELinjectionRatToxValDB_Uterotrophic_Hershberger_DB
=0.5mg/dayLELinjectionMouseToxValDB_Uterotrophic_Hershberger_DB

Showing 50 of 100 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
active
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL GENISTEIN
ChEMBL Phase
2
Adverse Events
7
Bioactivity
11
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

1 food-safety record found.

View full food safety profile →

Frequently Asked Questions

What is the NOAEL for Genistein?

Genistein has 100 NOAEL studies in the database. The lowest reported value is 0.00027024 mg via injection in Mouse. Source: ToxValDB_Uterotrophic_Hershberger_DB.

What regulatory lists include Genistein?

Genistein appears on 1 regulatory/inventory list including Canada; pharmaceutical. Source: EPA CPDat.

Is Genistein used in cosmetics?

Yes, Genistein is also indexed as a cosmetic ingredient under the name Soy Isoflavones. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Genistein come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.

Is Genistein used outside industrial chemicals?

Genistein also appears in cosmetics, pharmaceutical, food safety databases.