Danger GHS06GHS08 NOAEL Data Cosmetic Ingredient

Ergocalciferol

Also known as: Calciferol, (1S,3Z)-4-Methylene-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]cyclohexanol, Activated ergosterol, Calciferolum, EINECS 200-014-9 (+15 more)

CAS 50-14-6

Ergocalciferol (CAS 50-14-6) is a chemical substance with GHS signal word Danger; key hazard signal: H330; H311; H301; H372 **. Key regulatory status: 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat.

View cosmetic safety profile for Ergocalciferol →

SOURCE NOAEL studies
NOAEL studies
27
SOURCE Chemical inventory jurisdictions
Regulatory lists
9
SOURCE EU CLP Annex VI
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields
Name
Ergocalciferol
CAS Number
50-14-6
Molecular Formula
C28H44O
InChI Key
MECHNRXZTMCUDQ-RKHKHRCZSA-N
Monoisotopic Mass
396.339216
Synonyms
Calciferol(1S,3Z)-4-Methylene-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]cyclohexanolActivated ergosterolCalciferolumEINECS 200-014-9HyperkilIrradiated ergosta-5,7,22-trien-3-beta-olRodinec(3-beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10,(19),22-tetraen-3-ol9,10-Seco(5Z,7E,22E)-5,7,10(19),22-ergostatetraen-3-ol9,10-Secoergosta-5,7,10(19),22-tetraen-3-beta-olSorex C.R.

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 2 *; Acute Tox. 3 *; Acute Tox. 3 *; STOT RE 1H330; H311; H301; H372 **GHS06; GHS08Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records
Softener and conditionerFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 9 records
ListKeywordSource
inert_ingredient; non_food_use; PesticidesEPACPCat
active_ingredient; Europe; PesticidesEuropean CommissionCPCat
pharmaceuticalUS International Trade CommissionCPCat
Europe; supplementsEUCPCat
Europe; food_additive; supplementsEUCPCat
Canada; pharmaceuticalDrugBankDrugBank
Canada; pharmaceuticalDrugBankDrugBank
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 27 of 27 studies
ValueUnitEndpointRouteSpeciesSource
0.04393uMAC50--NTP ICE endocrine
68.59uMAC50--NTP ICE endocrine
0.03745uMACC--NTP ICE endocrine
38.95uMACC--NTP ICE endocrine
VS041H42XCUNIIFDA UNII substance identifier--openFDA substances
=10mg/kg bwLD50oralRatNTP ICE acute oral
0unitlessModel Score--NTP ICE endocrine
0.0286unitlessModel Score--NTP ICE endocrine
0.0908unitlessModel Score--NTP ICE endocrine
0.01mg/kg bw/dayNOAELoralratCOSMOS DB
0.25mg/kg bw/dayNOAELoraldogCOSMOS DB
0.5mg/kg bw/dayNOAELoralratCOSMOS DB
0.625mg/kg bw/dayNOAELoralratCOSMOS DB
0.825mg/kg bw/dayNOAELoralhorseCOSMOS DB
1.25mg/kg bw/dayNOAELoralmouseCOSMOS DB
1.9mg/kg bw/dayNOAELoralratCOSMOS DB
2.5mg/kg bw/dayNOAELoralratCOSMOS DB
2.9mg/kg bw/dayNOAELoralratCOSMOS DB
3.75mg/kg bw/dayNOAELoralratCOSMOS DB
4mg/kg bw/dayNOAELoralratCOSMOS DB
5mg/kg bw/dayNOAELoralratCOSMOS DB
7.5mg/kg bw/dayNOAELoralratCOSMOS DB
12.5mg/kg bw/dayNOAELoralratCOSMOS DB
50mg/kg bw/dayNOAELoralgerbilCOSMOS DB
76mg/kg bw/dayNOAELoralratCOSMOS DB
100mg/kg bw/dayNOAELoralratCOSMOS DB
299mg/kg bw/dayNOAELoralratCOSMOS DB

Showing 27 of 27 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
vitamin
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed ERGOCALCIFEROL
ChEMBL Phase
4
Adverse Events
9306
Bioactivity
8
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA 1 records

1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Ergocalciferol?

Ergocalciferol (CAS 50-14-6) is classified under EU CLP Annex VI as Acute Tox. 2 *; Acute Tox. 3 *; Acute Tox. 3 *; STOT RE 1 with signal word Danger. Hazard statements: H330; H311; H301; H372 **. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Ergocalciferol?

Ergocalciferol has 27 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.

What regulatory lists include Ergocalciferol?

Ergocalciferol appears on 7 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, active_ingredient; Europe; Pesticides, pharmaceutical, and 4 more. Source: EPA CPDat.

Is Ergocalciferol used in cosmetics?

Yes, Ergocalciferol is also indexed as a cosmetic ingredient under the name Ergocalciferol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Ergocalciferol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Ergocalciferol have different safety status in cosmetics vs industrial chemicals?

Ergocalciferol is classified GHS Danger (H330, H311, H301, H372) in the chemicals database but is allowed in EU cosmetics.

Is Ergocalciferol used outside industrial chemicals?

Ergocalciferol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.