Is Ergocalciferol safe in cosmetics?
Ergocalciferol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
MODERATE
Cosmetic Ingredient
Ergocalciferol
Also known as: Calciferol, (1S,3Z)-4-Methylene-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]cyclohexanol, Activated ergosterol, Calciferolum, EINECS 200-014-9 (+15 more)
INCI: ERGOCALCIFEROL
Ergocalciferol (CAS 50-14-6) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical and food safety data.
Function
Skin Conditioning
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
(1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol
InChIKey
MECHNRXZTMCUDQ-RKHKHRCZSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Primarily regulated as drug substance; no specific FDA restriction on cosmetic use; drug claims would trigger drug classification
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ergocalciferol.
Calculate MoS for your specific formulation with the MoS Calculator.
EPA ToxValDB — Toxicity Values
2 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | =23.7 mg/kg | Mouse | oral | - | ChemIDplus |
| LD50 | =10 mg/kg | Rat | oral | - | ChemIDplus |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Acute ToxicityHealth Hazard
Hazard Class and Category
Acute Tox. 2 *; Acute Tox. 3 *; Acute Tox. 3 *; STOT RE 1
Hazard Statements
- H330 Fatal if inhaled
- H311 Toxic in contact with skin
- H301 Toxic if swallowed
- H372 **
Inserted via ATP: CLP00
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (3)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| IN | banned | - | all cosmetics |
| CA | restricted | ≤25 μg/day average absorption | All cosmetics |
| KR | prohibited | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Softener and conditioner
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Editorial summary
Preliminary editorial summary for Ergocalciferol — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fda_food_additive
Known Synonyms
Calciferol
(1S,3Z)-4-Methylene-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]cyclohexanol
Activated ergosterol
Calciferolum
EINECS 200-014-9
Hyperkil
Irradiated ergosta-5,7,22-trien-3-beta-ol
Rodinec
(3-beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10,(19),22-tetraen-3-ol
9,10-Seco(5Z,7E,22E)-5,7,10(19),22-ergostatetraen-3-ol
9,10-Secoergosta-5,7,10(19),22-tetraen-3-beta-ol
Sorex C.R.
Ergocalciferolo
Ergocalciferolum
UNII-VS041H42XC
Disdrol
(1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol
(1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol
(1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(E,1R,4R)-1,4,5-trimethylhex-2-enyl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-1-cyclohexanol
(1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(E,1R,4R)-1,4,5-trimethylhex-2-enyl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-cyclohexan-1-ol
Chemical Function
Softener and conditioner
Flavouring and nutrient
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
active_ingredient; Europe; Pesticides
pharmaceutical
Europe; supplements
Europe; food_additive; supplements
Canada; pharmaceutical
Canada; pharmaceutical
active_ingredient; Europe; Pesticides
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ERGOCALCIFEROL
ChEMBL ID
CHEMBL1536
Max Phase
4
Adverse Event Associations
9306
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Vitamin D2 (Ergocalciferol)
Food Category
vitamins_minerals
Frequently Asked Questions
Is Ergocalciferol allowed in the EU?
Ergocalciferol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ergocalciferol do in cosmetics?
Ergocalciferol functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 50-14-6.
Is Ergocalciferol used outside cosmetics?
Ergocalciferol also appears in pharmaceutical and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ergocalciferol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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