Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Ergocalciferol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 0.625 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 0.01 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 299 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 76 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2.9 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 50 mg/kg bw/day | oral | gerbil | Special Toxicology Study | COSMOS_DB |
| NOAEL | 4 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 100 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 0.825 mg/kg bw/day | oral | horse | Short Term Toxicity | COSMOS_DB |
| NOAEL | 7.5 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
Expert Verdict
Significant data gaps for cosmetic risk assessment: no CIR monograph, no SCCS opinion, no dermal absorption data, no sensitization data. Systemic toxicity (hypercalcemia) well-characterized at high oral doses but not expected at cosmetic use levels.
Regulatory Flags
Frequently Asked Questions
Is Ergocalciferol safe in cosmetics?
Significant data gaps for cosmetic risk assessment: no CIR monograph, no SCCS opinion, no dermal absorption data, no sensitization data. Systemic toxicity (hypercalcemia) well-characterized at high oral doses but not expected at cosmetic use levels. The EU classifies Ergocalciferol as "permitted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is Ergocalciferol allowed in the EU?
Ergocalciferol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ergocalciferol do in cosmetics?
Ergocalciferol functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 50-14-6.
What is the Margin of Safety for Ergocalciferol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Ergocalciferol?
The NOAEL (No Observed Adverse Effect Level) for Ergocalciferol is 0.625 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Ergocalciferol compliance across multiple jurisdictions:
Related Ingredients
Is Ergocalciferol in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Ergocalciferol in your formulation.