What is the NOAEL for All-trans-Lycopene?
All-trans-Lycopene has 100 NOAEL studies in the database. The lowest reported value is 0.065 mg/kg bw/day via oral in Rat. Source: INCHEM_WHO_jecfa_jecmono_v58je01.
NOAEL Data
Cosmetic Ingredient
All-trans-Lycopene
Also known as: EINECS 207-949-1, UNII-SB0N2N0WV6, Mexoryl SAQ, Tomat-O-Red, Redivivo (+2 more)
CAS 502-65-8
All-trans-Lycopene (CAS 502-65-8) is a chemical substance. Key regulatory status: 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
All-trans-Lycopene
CAS Number
502-65-8
DTXSID
DTXSID2046593
Molecular Formula
C40H56
InChI Key
OAIJSZIZWZSQBC-GYZMGTAESA-N
Monoisotopic Mass
536.438202
Synonyms
EINECS 207-949-1UNII-SB0N2N0WV6Mexoryl SAQTomat-O-RedRedivivo(6E,8E,10E,12E,14E,16E,18E,20E,22E,24E,26E)-2,6,10,14,19,23,27,31-octamethyldotriaconta-2,6,8,10,12,14,16,18,20,22,24,26,30-tridecaeneLycopene 7
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
DyeAntioxidantFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care | European Commission | CosIng |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Europe; Personal care | European Commission | CosIng |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| range:0-0.0650.065 | mg/kg bw/day | ADI | oral | Rat | INCHEM_WHO_jecfa_jecmono_v58je01 |
| range:0-0.0650.065 | mg/kg bw/day | ADI | oral | Rat | INCHEM_WHO_jecfa_jecmono_v58je01 |
| range:0-300.0821917808219178 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| range:0-300.0821917808219178 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| range:0-0.30.3 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v58je01 |
| range:0-0.30.3 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v58je01 |
| range:0-0.50.5 | mg/kg bw/day | ADI | - | Human; Rat | INCHEM_WHO_jecfa_jecmono_v58je01 |
| range:0-0.50.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =0.5 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.5 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| range:0-0.50.5 | mg/kg bw/day | ADI | - | Human; Rat | INCHEM_WHO_jecfa_jecmono_v58je01 |
| range:0-0.50.5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| range:0-0.60.6 | mg/kg bw/day | ADI | - | Rat | INCHEM_WHO_jecfa_jecmono_v58je01 |
| range:0-0.60.6 | mg/kg bw/day | ADI | - | Rat | INCHEM_WHO_jecfa_jecmono_v58je01 |
| range:0-77 | mg/kg bw/day | ADI | oral | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| range:0-77 | mg/kg bw/day | ADI | oral | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =10 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v58je01 |
| =10 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v58je01 |
| range:0-1111 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| range:0-1111 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| range:0-1212 | mg/kg bw/day | ADI | - | Rat | INCHEM_WHO_jecfa_jecmono_v58je01 |
| range:0-1212 | mg/kg bw/day | ADI | - | Rat | INCHEM_WHO_jecfa_jecmono_v58je01 |
| range:0-2525 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| range:0-2525 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| range:0-3030 | mg/kg bw/day | ADI | - | Human | INCHEM_WHO_jecfa_jecmono_v62je01 |
| range:0-3030 | mg/kg bw/day | ADI | - | Human | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =99 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =99 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =120 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =120 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =204 | mg/kg bw/day | ADI | oral | Human | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =204 | mg/kg bw/day | ADI | oral | Human | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =221 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =221 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =250 | mg/kg bw/day | ADI | oral | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =250 | mg/kg bw/day | ADI | oral | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =293 | mg/kg bw/day | ADI | oral | Human | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =293 | mg/kg bw/day | ADI | oral | Human | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =350 | mg/kg bw/day | ADI | oral | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =350 | mg/kg bw/day | ADI | oral | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =400 | mg/kg bw/day | ADI | oral | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =400 | mg/kg bw/day | ADI | oral | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =450 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =450 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =566 | mg/kg bw/day | ADI | oral | Human | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =566 | mg/kg bw/day | ADI | oral | Human | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =832 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =832 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v62je01 |
| =0.5 | mg/kg bw/day | ADI (group) | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.5 | mg/kg bw/day | ADI (group) | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
Showing 50 of 100 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
LYCOPENE
ChEMBL Phase
3
Adverse Events
154
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
2 records
E160d — ADI: 0.5 mg/kg bw | FDA GRAS: FDA has no questions; some uses may require a color additive listing
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include All-trans-Lycopene?
All-trans-Lycopene appears on 3 regulatory/inventory lists including Europe; Personal care, Canada; pharmaceutical, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is All-trans-Lycopene used in cosmetics?
Yes, All-trans-Lycopene is also indexed as a cosmetic ingredient under the name Lycopene Cosmetic. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for All-trans-Lycopene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is All-trans-Lycopene used outside industrial chemicals?
All-trans-Lycopene also appears in cosmetics, pharmaceutical, food safety, cannabis databases.