What is the NOAEL for Apigenin?
Apigenin has 24 NOAEL studies in the database. The lowest reported value is 0 fraction in Rat. Source: NTP ICE adme parameters.
NOAEL Data
Cosmetic Ingredient
Apigenin
Also known as: Flavone, 4',5,7-trihydroxy-, Spigenin, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone, 5-18-04-00574, BRN 0262620 (+9 more)
CAS 520-36-5
Apigenin (CAS 520-36-5) is a chemical substance. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
SOURCE
NOAEL studies
NOAEL studies
24
SOURCE
Chemical inventory jurisdictions
Regulatory lists
4
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
Apigenin
CAS Number
520-36-5
Molecular Formula
C15H10O5
InChI Key
KZNIFHPLKGYRTM-UHFFFAOYSA-N
Monoisotopic Mass
270.052823
Synonyms
Flavone, 4',5,7-trihydroxy-Spigenin5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone5-18-04-00574BRN 0262620EINECS 208-292-32-(p-Hydroxyphenyl)-5,7-dihydroxychromoneUNII-7V515PI7F64',5,7-Trihydroxy-Flavone4,5, 7-Trihydroxyflavone5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
AntioxidantSoftener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 24 of 24 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 2.078 | uM | AC50 | - | - | NTP ICE endocrine |
| 14.47 | uM | AC50 | - | - | NTP ICE endocrine |
| 3700 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| 5200 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| 9500 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| 1.000e+4 | nM | AC50/EC50/IC50 | - | - | NTP ICE endocrine |
| 0.9358 | uM | ACC | - | - | NTP ICE endocrine |
| 8.745 | uM | ACC | - | - | NTP ICE endocrine |
| 85.7 | uL/min/10^6 cells | Clint | - | Rat | NTP ICE adme parameters |
| 138 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| 1600 | nM | EC50 | - | - | NTP ICE endocrine |
| 7V515PI7F6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0 | fraction | Fu | - | Rat | NTP ICE adme parameters |
| 0.0000957 | fraction | Fu | - | Human | NTP ICE adme parameters |
| 0.1 | nM | LEL | - | - | NTP ICE endocrine |
| =5 | mg/kg bw/day | LEL | oral | Rat | ToxValDB Uterotrophic Hershberger DB |
| 1000 | nM | LEL | - | - | NTP ICE endocrine |
| 5 | mg/kg bw/day | LOEL | Oral | Rat | NTP ICE endocrine |
| 0 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.0403 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.156 | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.307 | unitless | Model Score | - | - | NTP ICE endocrine |
| 57.1 | nM | PC50 | - | - | NTP ICE endocrine |
| 128.4 | % | Uterine weight increase vs control | Oral | Rat | NTP ICE endocrine |
Showing 24 of 24 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
APIGENIN
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
11
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Apigenin?
Apigenin appears on 1 regulatory/inventory list including Canada; pharmaceutical. Source: EPA CPDat.
Is Apigenin used in cosmetics?
Yes, Apigenin is also indexed as a cosmetic ingredient under the name Apigenin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Apigenin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Apigenin used outside industrial chemicals?
Apigenin also appears in cosmetics, pharmaceutical, food safety, cannabis databases.