Is Apigenin safe in cosmetics?
Apigenin has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Antioxidant
Apigenin
Also known as: Flavone, 4',5,7-trihydroxy-, Spigenin, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone, 5-18-04-00574, BRN 0262620 (+9 more)
INCI: APIGENIN
Apigenin (CAS 520-36-5) is a cosmetic antioxidant functioning as Antioxidant, Hair Conditioning, Anti-Inflammatory. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 520-36-5 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, Hair Conditioning, Anti-Inflammatory
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
InChIKey
KZNIFHPLKGYRTM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No GRAS classification. No specific FDA restrictions for cosmetic use.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Apigenin.
Calculate MoS for your specific formulation with the MoS Calculator.
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: other
Receptor targets: ERα, ERβ
LOEC: 100 nM
EU status: allowed
agonist
Additional Ingredient Properties
5 property records from structured ingredient metadata.
acne
{"cas_number": "520-36-5", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_…
anti_aging
{"anti_aging_claim": "anti-inflammatory, antioxidant-protection", "mechanism_of_action": "Bioactive compound, specialized mechanism", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "8-15", "clinical_study_duration_weeks": "12", "sample_size": "35", "double_blind": "No", "placebo_controlled": "Yes", "published_journal…
anti_pollution
{"cas_number": "520-36-5", "ingredient_class": "antioxidant_pollution_shield", "primary_mechanism": "free_radical_scavenging", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation…
antioxidant
{"cas_number": "520-36-5", "antioxidant_class": "flavonoid", "chemical_subclass": "flavone", "molecular_weight_daltons": "270.24", "orac_value_umol_te_per_g": "13900", "dpph_radical_scavenging_ic50_ug_per_ml": "12-21", "abts_trolox_equivalent": "not available", "singlet_oxygen_quenching": "not available", "superoxide_dismutase_mimetic": "not available", "hydroxyl_radical_scavenging": "not availabl…
depigmentation
{"cas_number": "520-36-5", "ingredient_class": "tyrosinase_inhibitor", "primary_mechanism_of_action": "Flavone with tyrosinase and MITF downregulation", "secondary_mechanisms": "Variable", "molecular_target": "tyrosinase", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_clinical": "15-30", "on…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Apigenin.
Regulatory Flags
endocrine_disruptor
Known Synonyms
Flavone, 4',5,7-trihydroxy-
Spigenin
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone
5-18-04-00574
BRN 0262620
EINECS 208-292-3
2-(p-Hydroxyphenyl)-5,7-dihydroxychromone
UNII-7V515PI7F6
4',5,7-Trihydroxy-Flavone
4,5, 7-Trihydroxyflavone
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
LY 080400
UCCF 031
Chemical Function
Antioxidant
Softener and conditioner
Regulatory Lists
Canada; pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
APIGENIN
ChEMBL ID
CHEMBL28
Frequently Asked Questions
Is Apigenin allowed in the EU?
Apigenin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Apigenin do in cosmetics?
Apigenin functions as: Antioxidant, Hair Conditioning, Anti-Inflammatory. It is classified as a Antioxidant in our database. CAS number: 520-36-5.
Is Apigenin used outside cosmetics?
Apigenin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Apigenin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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