Apigenin

INCI: APIGENIN

CAS Number
520-36-5
Function
Antioxidant, Hair Conditioning, Anti-Inflammatory
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No GRAS classification. No specific FDA restrictions for cosmetic use.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Apigenin is a naturally occurring flavone with demonstrated anti-inflammatory, barrier repair, and collagen synthesis properties, permitted in the EU without concentration restrictions, though human dermal absorption data under standardized conditions is lacking.

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Concern Level: Low

Regulatory Flags

endocrine_disruptor

Frequently Asked Questions

Is Apigenin safe in cosmetics?

Apigenin is a naturally occurring flavone with demonstrated anti-inflammatory, barrier repair, and collagen synthesis properties, permitted in the EU without concentration restrictions, though human dermal absorption data under standardized conditions is lacking. The EU classifies Apigenin as "permitted". Safety rating: GOOD.

Is Apigenin allowed in the EU?

Apigenin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Apigenin do in cosmetics?

Apigenin functions as: Antioxidant, Hair Conditioning, Anti-Inflammatory. It is classified as a Antioxidant in our database. CAS number: 520-36-5.

What is the Margin of Safety for Apigenin?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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