What is the NOAEL for 1,2-Propylene glycol?
1,2-Propylene glycol has 97 NOAEL studies in the database. The lowest reported value is -3 % via Dermal. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1,2-Propylene glycol
Also known as: alpha-Propylene glycol, (+/-) 1,2-Propanediol, (RS)-1,2-Propanediol, dl-Propylene glycol, 3-01-00-02142 (+15 more)
CAS 57-55-6
1,2-Propylene glycol (CAS 57-55-6) is a chemical substance. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
97
SOURCE
chemical inventory jurisdictions
Regulatory lists
60
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
1,2-Propylene glycol
CAS Number
57-55-6
DTXSID
DTXSID0021206
Molecular Formula
C3H8O2
InChI Key
DNIAPMSPPWPWGF-UHFFFAOYSA-N
Monoisotopic Mass
76.052429
Synonyms
alpha-Propylene glycol(+/-) 1,2-Propanediol(RS)-1,2-Propanedioldl-Propylene glycol3-01-00-02142BRN 1340498Caswell No. 713EINECS 200-338-0EPA Pesticide Chemical Code 068603FEMA No. 2940(+-)-1,2-Propanediol(+-)-Propylene glycol
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Hazard Statements | No hazard classification according to GHS criteria |
| Short-term Effects | The substance is mildly irritating to the eyes and respiratory tract. Ingestion of large amounts could cause metabolic acidosis. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
SolventStabilizing agentHumectantFragranceProcessing aids not otherwise specifiedSoftener and conditionerViscosity modifier
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
60 records
| List | Keyword | Source |
|---|---|---|
| air; detected; emissions; Europe; Vehicle - car interior - auto air freshener | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - liniment | Danish Environmental Protection Agency | Danish EPA |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| artificial_saliva; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| consumer_product | P&G | Proctor & Gamble |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| Cleaning products and household care - shoes; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - shoes; Europe | Danish Environmental Protection Agency | Danish EPA |
| fracking; water | NY Department of Conservation | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Arts and crafts/Office supplies - home office - pens and markers; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 97 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=25 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| =25 | mg/kg bw/day | ADI | oral | Human | INCHEM_WHO_pims_chemical_pim443 |
| =25 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =25 | mg/kg bw/day | ADI | oral | Human | INCHEM_WHO_pims_chemical_pim443 |
| =25 | mg/kg bw/day | ADI | oral | Human | INCHEM_WHO_pims_chemical_pim443 |
| =25 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =25 | mg/kg bw/day | ADI | oral | Human | INCHEM_WHO_pims_chemical_pim443 |
| >200 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| >532.665 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 833.3 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| <1000 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 5000 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| =10 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =168 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| -3 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| -0.9 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.6 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 1.8 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.3 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 1.3 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| >2000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 4 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 6DC9Q167V3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6DC9Q167V3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6DC9Q167V3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6DC9Q167V3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2400 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 1.15 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.209 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.24 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 9300 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 15520 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 41850 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =20000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >21000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =22000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| <33700 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =5000 | mg/m3 | LEL | inhalation | Dog | ToxValDB_ECHA_IUCLID |
| =41000 | mg/m3 | LEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =80919.4 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =158.727 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB_ATSDR_MRLs |
| =158.727 | mg/m3 | LOAEL | inhalation | Rat (Sprague Dawley; M/F) | ATSDR_toxval_ATSDR_MRLs.xlsx |
| 5000 | mg/kg bw/day | LOAEL | oral | dog | COSMOS_DB |
| =5200 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_PPRTV_(CPHEA) |
| =160 | mg/m3 | LOEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| >180 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| =0.0280106 | mg/m3 | MRL | inhalation | Human | ToxValDB_ATSDR_MRLs |
Showing 50 of 97 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Propane-1,2-diol | 200-338-0 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
humectant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PROPYLENE GLYCOL
ChEMBL Phase
3
Adverse Events
67
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: 25 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 1,2-Propylene glycol?
1,2-Propylene glycol appears on 29 regulatory/inventory lists including air; detected; emissions; Europe; Vehicle - car interior - auto air freshener, detected; Europe; Vehicle - car interior, detected; Europe; Personal care - liniment, and 26 more. Source: EPA CPDat.
Is 1,2-Propylene glycol used in cosmetics?
Yes, 1,2-Propylene glycol is also indexed as a cosmetic ingredient under the name Propylene Glycol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,2-Propylene glycol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 1,2-Propylene glycol used outside industrial chemicals?
1,2-Propylene glycol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.