What is the NOAEL for Testosterone?
Testosterone has 100 NOAEL studies in the database. The lowest reported value is 0.002 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.
NOAEL Data
Prop 65
REACH Registered
Cosmetic Ingredient
Testosterone
Also known as: (17β)-17-Hydroxyandrost-4-en-3-one, Nasobol, Oreton, Teslen, Testim (+15 more)
CAS 58-22-0
Testosterone (CAS 58-22-0) is a chemical substance; key hazard signal: cancer. Key regulatory status: California Proposition 65, REACH registered, 32 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, CA Prop 65.
Cross-Vertical Regulatory Divergence
Testosterone is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H350, H351, H360, H361, H362, H372, H400).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
32
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Testosterone
CAS Number
58-22-0
DTXSID
DTXSID8022371
Molecular Formula
C19H28O2
InChI Key
MUMGGOZAMZWBJJ-DYKIIFRCSA-N
Monoisotopic Mass
288.20893
Synonyms
(17β)-17-Hydroxyandrost-4-en-3-oneNasobolOretonTeslenTestimVirormoneAndrost-4-en-3-one, 17-hydroxy-, (17.beta.)-Androst-4-en-3-one, 17-hydroxy-, (17beta)-(8R,9S,10R,13S,14S,17S)-17-Hydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one7β-Hydroxyandrost-4-en-3-oneNatestoNoseafix
California Proposition 65
California OEHHA listing status and toxicity category.
SOURCE
California OEHHA Proposition 65 List
1 records
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
Softener and conditionerPharmaceutical
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
32 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| pharmaceutical | DEA | U.S. Drug Enforcement Administration (DEA) |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; wastewater | Minnesota Pollution Control Agency | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| pharmaceutical; prohibited | World Anti-Doping Agency | World Anti-Doping Agency |
| pharmaceutical; prohibited | World Anti-Doping Agency | World Anti-Doping Agency |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.0042 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.04 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.07 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.1 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.182 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.3 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.35 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.4 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.42 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.5 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.505 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.51 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.59 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.62 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.631 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.7943 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.8 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.862 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.9 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.979 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 0.9812 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 1 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 1.2 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 1.202 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 1.3 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 1.6 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 2 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 2.1 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 2.291 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 2.5 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 2.6 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 2.722 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 2.8 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 3.9 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 3.96 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 4 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 4.2 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 4.4 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 4.5 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 4.571 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 4.6 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 5 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 5.1 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 5.623 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 5.8 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 6 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 6.9 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 6.95 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 7.4 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 8.31 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Testosterone | 200-370-5 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
TESTOSTERONE
ChEMBL Phase
4
Adverse Events
2892
Bioactivity
19
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Testosterone?
Testosterone appears on 8 regulatory/inventory lists including pharmaceutical, detected; MN Chemical Screening; surface_water, detected; MN Chemical Screening; wastewater, and 5 more. Source: EPA CPDat.
Is Testosterone on the California Proposition 65 list?
Yes, Testosterone is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Is Testosterone used in cosmetics?
Yes, Testosterone is also indexed as a cosmetic ingredient under the name Testosterone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Testosterone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, California Proposition 65, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Testosterone have different safety status in cosmetics vs industrial chemicals?
Testosterone is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H350, H351, H360, H361, H362, H372, H400).
Is Testosterone used outside industrial chemicals?
Testosterone also appears in cosmetics, pharmaceutical, cannabis databases.