NOAEL Data REACH Registered Cosmetic Ingredient

C.I. Acid Orange 7

Also known as: Acid Orange II, EC No.: 211-199-0, Benzenesulfonic acid, p-(2-hydroxy-1-naphthylazo)-, sodium salt, D&C Orange 4, Acid Leather Orange Extra (+14 more)

CAS 633-96-5

C.I. Acid Orange 7 (CAS 633-96-5) is a chemical substance. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for Orange 4 (CI 15510) →

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 23 fields

Name

C.I. Acid Orange 7

CAS Number

633-96-5

Molecular Formula

C16H12N2O4S.Na

InChI Key

CQPFMGBJSMSXLP-UHFFFAOYSA-M

Synonyms

Acid Orange IIEC No.: 211-199-0Benzenesulfonic acid, p-(2-hydroxy-1-naphthylazo)-, sodium saltD&C Orange 4Acid Leather Orange ExtraAcid Leather Orange Extra GAcid Leather Orange Extra PRWAcid Leather Orange PRWEINECS 211-199-0p-((2-Hydroxy-1-naphthyl)azo)benzenesulfonic acid sodium salt4-((2-Hydroxy-1-naphthyl)azo)benzenesulfonic acid, sodium saltKayaku Acid Orange II

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 53 records

DyeFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 12 records

List	Keyword	Source
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care - hair coloring	Danish Environmental Protection Agency	Danish EPA
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
IFRA Transparency	IFRA	IFRA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - specialized bath products - bath salts	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care - hair styling and care - shampoo	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
pharmaceutical	FDA	United States Food and Drug Administration (FDA)
Personal care	FDA	United States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 26 of 26 studies

Value	Unit	Endpoint	Route	Species	Source
2.5	mg/kg bw/day	-	-	-	Regulatory source
2.5	mg/kg bw/ day	-	dermal	rabbit	Regulatory source
2.5	mg/kg bw/d	-	oral	rat	Regulatory source
5	mg/kg	-	oral	rat	Regulatory source
5	mg/kg bw/day	-	-	human	Regulatory source
=0.176	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
Q1LIY3BO0U	UNII	FDA UNII substance identifier	-	-	openFDA substances
=5	mg/kg bw/day	LOAEL	oral	Rat	ECHA
=100	mg/kg bw/day	LOAEL	oral	Rat	ECHA
0	unitless	Model Score	-	-	NTP ICE endocrine
=0.83	mg/kg bw/d	NOAEL	oral	rat	SCCS Opinion
=2.5	mg/kg bw/day	NOAEL	-	-	SCCS Opinion
=2.5	mg/kg bw/ day	NOAEL	dermal	rabbit	SCCS Opinion
=2.5	mg/kg bw/d	NOAEL	oral	rat	SCCS Opinion
=2.5	mg/kg	NOAEL	dermal	rabbit	SCCNFP Opinion
=5	mg/kg bw/day	NOAEL	-	human	SCCS Opinion
=5	mg/kg bw/d	NOAEL	oral	rat	SCCS Opinion
=5	mg/kg	NOAEL	oral	rat	SCCNFP Opinion
=50	%	NOAEL	oral	rat	SCCS Opinion
=1000	mg/kg bw/day	NOAEL	oral	Rat	ECHA
=0.83	mg/kg bw/d	dermal absorption	oral	rat	Regulatory source
5	mg/kg	dermal absorption	oral	rat	Regulatory source
5	mg/kg bw/d	dermal absorption	oral	rat	Regulatory source
50	%	dermal absorption	oral	rat	Regulatory source
2.5	mg/kg	genotoxicity	oral	rat	Regulatory source
2.5	mg/kg	repeated dose toxicity	dermal	rabbit	Regulatory source

Showing 26 of 26 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	Sodium 4-[(2-hydroxy-1-naphthyl)azo]benzenesulphonate	211-199-0	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 2 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1536/14	23 September 2014	safe	0.5%	moderate sensitiser
SCCS/1437/11	22 March 2011	safe	0.5%	sensitisation potential not excluded

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL2028473

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA 1 records

E111 — ADI: DECISION POSTPONED mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for C.I. Acid Orange 7?

C.I. Acid Orange 7 has 26 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.

What regulatory lists include C.I. Acid Orange 7?

C.I. Acid Orange 7 appears on 8 regulatory/inventory lists including Europe; Personal care - hair coloring, inert_ingredient; non_food_use; Pesticides, IFRA Transparency, and 5 more. Source: EPA CPDat.

Is C.I. Acid Orange 7 used in cosmetics?

Yes, C.I. Acid Orange 7 is also indexed as a cosmetic ingredient under the name Orange 4 (CI 15510). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for C.I. Acid Orange 7 come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is C.I. Acid Orange 7 used outside industrial chemicals?

C.I. Acid Orange 7 also appears in cosmetics, pharmaceutical, food safety, cannabis databases.