Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Orange 4 (CI 15510). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 2.5 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Orange 4 (CI 15510) is generally considered safe for use as a direct hair colouring agent.
Regulatory Flags
Frequently Asked Questions
Is Orange 4 (CI 15510) safe in cosmetics?
Orange 4 (CI 15510) is generally considered safe for use as a direct hair colouring agent. The EU classifies Orange 4 (CI 15510) as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.
Is Orange 4 (CI 15510) allowed in the EU?
Orange 4 (CI 15510) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Orange 4 (CI 15510) do in cosmetics?
Orange 4 (CI 15510) functions as: Direct (non-reactive) hair colouring agent. It is classified as a Colorant in our database. CAS number: 633-96-5.
What is the Margin of Safety for Orange 4 (CI 15510)?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Orange 4 (CI 15510)?
The NOAEL (No Observed Adverse Effect Level) for Orange 4 (CI 15510) is 2.5 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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