Danger GHS06GHS08 NOAEL Data Cosmetic Ingredient

Vitamin D3

Also known as: Cholecalciferol, 9,10-Secocholesta-5,7,10(19)-trien-3-ol, (3.beta.,5Z,7E)-, CHOLECALCIFEROL; (VIT. D3), (3S,5Z,7E)-9,10-Secocholesta-5,7,10-trien-3-ol, Activated 7-dehydrocholesterol (+15 more)

CAS 67-97-0

Vitamin D3 (CAS 67-97-0) is a chemical substance with GHS signal word Danger; key hazard signal: H330; H310; H300; H372. Key regulatory status: 35 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat.

View cosmetic safety profile for CHOLECALCIFEROL →

SOURCE noael studies public
NOAEL studies
33
SOURCE chemical inventory jurisdictions
Regulatory lists
35
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields
Name
Vitamin D3
CAS Number
67-97-0
DTXSID
DTXSID6026294
Molecular Formula
C27H44O
InChI Key
QYSXJUFSXHHAJI-YRZJJWOYSA-N
Monoisotopic Mass
384.339216
Synonyms
Cholecalciferol9,10-Secocholesta-5,7,10(19)-trien-3-ol, (3.beta.,5Z,7E)-CHOLECALCIFEROL; (VIT. D3)(3S,5Z,7E)-9,10-Secocholesta-5,7,10-trien-3-olActivated 7-dehydrocholesterolCholecalciferol, D3CholecalciferolumColecalcipherol7-Dehydrocholesterol, irradiated7-Dehydrocholestrol, activatedEINECS 200-673-2Irradiated 7-dehydrocholesterol

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 2; Acute Tox. 2; Acute Tox. 2; STOT RE 1H330; H310; H300; H372GHS06; GHS08Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 19 records
Softener and conditionerPharmaceuticalBiocideFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 35 records
ListKeywordSource
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesCalifornia Department of Pesticide RegulationState of California
active_ingredient; Europe; PesticidesEuropean CommissionCPCat
active_ingredient; AustraliaAustralian Pesticides and Veterinary Medicines AuthorityCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; agricultural; PesticidesUSDAUnited States Department of Agriculture (USDA)
active_ingredient; agricultural; PesticidesUSDAUnited States Department of Agriculture (USDA)
Europe; supplementsEUCPCat
Europe; food_additive; supplementsEUCPCat
Canada; pharmaceuticalDrugBankDrugBank
Canada; pharmaceuticalDrugBankDrugBank
active_ingredient; AustraliaAustralian Pesticides and Veterinary Medicines AuthorityCPCat
pharmaceuticalUS International Trade CommissionCPCat
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
inert_ingredient; PesticidesEPACPCat
inert_ingredient; non_food_use; PesticidesEPACPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 33 of 33 studies
ValueUnitEndpointRouteSpeciesSource
1C6V77QF41UNIIFDA UNII substance identifier--openFDA substances
1C6V77QF41UNIIFDA UNII substance identifier--openFDA substances
1C6V77QF41UNIIFDA UNII substance identifier--openFDA substances
1C6V77QF41UNIIFDA UNII substance identifier--openFDA substances
=0.0003mg/orgLOELoralRatToxValDB_ECOTOX
=0.00045mg/kg bw/dayLOELinjectionRatToxValDB_ECOTOX
=2.5mg/orgLOELinjectionRatToxValDB_ECOTOX
=12.5mg/kg bw/dayLOELinjectionRatToxValDB_ECOTOX
=100IULOELoralRatToxValDB_ECOTOX
=1350ug/kg dietLOELoralDogToxValDB_ECOTOX
=5000IU/kgLOELoralRatToxValDB_ECOTOX
=20000IU/kgLOELoralRatToxValDB_ECOTOX
=54000IU/kg dietLOELoralDogToxValDB_ECOTOX
0.00085mg/kg bw/dayNOAELoralswineCOSMOS_DB
0.01mg/kg bw/dayNOAELoralratCOSMOS_DB
0.019mg/kg bw/dayNOAELoralrabbitCOSMOS_DB
0.03mg/kg bw/dayNOAELoraldogCOSMOS_DB
0.0364mg/kg bw/dayNOAELoralcatCOSMOS_DB
0.063mg/kg bw/dayNOAELoralratCOSMOS_DB
0.1mg/kg bw/dayNOAELoralratCOSMOS_DB
0.25mg/kg bw/dayNOAELoralrabbitCOSMOS_DB
0.375mg/kg bw/dayNOAELoralcatCOSMOS_DB
0.495mg/kg bw/dayNOAELoralswineCOSMOS_DB
0.5mg/kg bw/dayNOAELoralratCOSMOS_DB
0.625mg/kg bw/dayNOAELoralratCOSMOS_DB
1.7mg/kg bw/dayNOAELoralratCOSMOS_DB
1.9mg/kg bw/dayNOAELoralratCOSMOS_DB
2.7mg/kg bw/dayNOAELoralratCOSMOS_DB
3mg/kg bw/dayNOAELoralratCOSMOS_DB
4mg/kg bw/dayNOAELoralswineCOSMOS_DB
10mg/kg bw/dayNOAELoralrodentCOSMOS_DB
12.5mg/kg bw/dayNOAELoralratCOSMOS_DB
=10000IU/kgNOELoralRatToxValDB_ECOTOX

Showing 33 of 33 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
active
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHOLECALCIFEROL
ChEMBL Phase
4
Adverse Events
17331
Bioactivity
12
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Vitamin D3?

Vitamin D3 (CAS 67-97-0) is classified under EU CLP Annex VI as Acute Tox. 2; Acute Tox. 2; Acute Tox. 2; STOT RE 1 with signal word Danger. Hazard statements: H330; H310; H300; H372. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Vitamin D3?

Vitamin D3 has 33 NOAEL studies in the database. The lowest reported value is 1C6V77QF41 UNII. Source: openFDA substances.

What regulatory lists include Vitamin D3?

Vitamin D3 appears on 11 regulatory/inventory lists including active_ingredient; Pesticides, active_ingredient; Europe; Pesticides, active_ingredient; Australia, and 8 more. Source: EPA CPDat.

Is Vitamin D3 used in cosmetics?

Yes, Vitamin D3 is also indexed as a cosmetic ingredient under the name CHOLECALCIFEROL. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Vitamin D3 come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Vitamin D3 have different safety status in cosmetics vs industrial chemicals?

Vitamin D3 is prohibited in EU cosmetics but has active industrial GHS classifications (H330, H310, H300, H372).

Is Vitamin D3 used outside industrial chemicals?

Vitamin D3 also appears in cosmetics, pharmaceutical, food safety, cannabis databases.