What is the NOAEL for Iron?
Iron has 19 NOAEL studies in the database. The lowest reported value is 0.8 mg/kg bw/day in Consumers. Source: EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Iron
Also known as: Iron (Fe), EINECS 231-096-4, Ferrous iron, Copy Powder CS 105-175, Diseases (animal), iron overload (+15 more)
CAS 7439-89-6
Iron (CAS 7439-89-6) is a chemical substance. Key regulatory status: REACH registered, 29 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, OSHA.
Cross-Vertical Regulatory Divergence
Iron is classified GHS Danger (H228, H251, H319, H335) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
19
SOURCE
chemical inventory jurisdictions
Regulatory lists
29
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Iron
CAS Number
7439-89-6
DTXSID
DTXSID5043710
Molecular Formula
Fe
InChI Key
XEEYBQQBJWHFJM-UHFFFAOYSA-N
Monoisotopic Mass
55.934936
Synonyms
Iron (Fe)EINECS 231-096-4Ferrous ironCopy Powder CS 105-175Diseases (animal), iron overloadDiseases, iron overloadUNII-E1UOL152H7Blood stopFerrum metallicum26FeEisenFe
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
4 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 1 mg/m³ (Construction and Maritime Industries ONLY) | - | 1 | N |
| NIOSH | TWA | 1 mg/m³ | - | 1 | N |
| ACGIH | TWA | 1 mg/m³ [1990] | - | 1 | N |
| CAL/OSHA | TWA | 1 mg/m³ | - | 1 | N |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
OpaciferReducing agentAnti-caking agentSoftener and conditionerBinder
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
29 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| Europe; supplements | EU | CPCat |
| Europe; pharmaceutical | European Medicines Agency | PROTECT ADR database |
| detected; Europe; Personal care - make-up and related - eye liner | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - body paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Construction and building materials; detected | the Vrije Universiteit Amsterdam, the Ecology Center, & the University of Notre Dame | Healthy Stuff |
| Construction and building materials; detected | the Vrije Universiteit Amsterdam, the Ecology Center, & the University of Notre Dame | Healthy Stuff |
| - | Journal of Chemical Engineering & Process Technology | Published Articles |
| - | Environmental Research | Published Articles |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| Canada; pharmaceutical | DrugBank | DrugBank |
| fracking; water | NY Department of Conservation | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 19 of 19 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.8 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx |
| =3 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| E1UOL152H7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| E1UOL152H7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| E1UOL152H7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| E1UOL152H7 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 66 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 130 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 149 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 173 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 624 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1297 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 1500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 4500 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| =0.7 | mg/kg bw/day | RfD | oral | Human | ToxValDB_RSL |
Showing 19 of 19 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Iron | 231-096-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
iron
ChEMBL Phase
Not listed
Adverse Events
5257
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Iron?
Iron appears on 14 regulatory/inventory lists including active_ingredient; Pesticides, Europe; supplements, Europe; pharmaceutical, and 11 more. Source: EPA CPDat.
What are the occupational exposure limits for Iron?
Occupational exposure limits for Iron are set by OSHA, NIOSH, ACGIH. 4 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Iron used in cosmetics?
Yes, Iron is also indexed as a cosmetic ingredient under the name Iron Powder. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Iron come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Iron have different safety status in cosmetics vs industrial chemicals?
Iron is classified GHS Danger (H228, H251, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Is Iron used outside industrial chemicals?
Iron also appears in cosmetics, pharmaceutical, food safety, cannabis databases.