What is the NOAEL for 3-Methylindole?
3-Methylindole has 8 NOAEL studies in the database. The lowest reported value is 9W945B5H7R UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
3-Methylindole
Also known as: EINECS 201-471-7, FEMA No. 3019, UNII-9W945B5H7R, 3-MI, Skatol (+2 more)
CAS 83-34-1
3-Methylindole (CAS 83-34-1) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
3-Methylindole
CAS Number
83-34-1
DTXSID
DTXSID8021775
Molecular Formula
C9H9N
InChI Key
ZFRKQXVRDFCRJG-UHFFFAOYSA-N
Monoisotopic Mass
131.073499
Synonyms
EINECS 201-471-7FEMA No. 3019UNII-9W945B5H7R3-MISkatolb-Methylindolebeta-methylindole
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
7 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| Europe | European Commission | Fl@vis |
| detected; wastewater | USGS | United States Geological Survey (USGS) |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 9W945B5H7R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9W945B5H7R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9W945B5H7R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9W945B5H7R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1296 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =3450 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3-methylindole | 201-471-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1329793
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 3-Methylindole?
3-Methylindole appears on 6 regulatory/inventory lists including detected; drinking_water; MN Chemical Screening, Europe, detected; wastewater, and 3 more. Source: EPA CPDat.
Is 3-Methylindole used in cosmetics?
Yes, 3-Methylindole is also indexed as a cosmetic ingredient under the name Skatole. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 3-Methylindole come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 3-Methylindole used outside industrial chemicals?
3-Methylindole also appears in cosmetics, pharmaceutical, cannabis databases.