Is Skatole safe in cosmetics?
Skatole has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Skatole
Also known as: EINECS 201-471-7, FEMA No. 3019, UNII-9W945B5H7R, 3-MI, Skatol (+2 more)
INCI: SKATOLE
Skatole (CAS 83-34-1) is a cosmetic cosmetic ingredient functioning as Fragrance (animalic/fecal/floral note in trace amounts). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 83-34-1 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance (animalic/fecal/floral note in trace amounts)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3-methyl-1H-indole
InChIKey
ZFRKQXVRDFCRJG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; FEMA GRAS \#3019 for flavor use; no specific cosmetic restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Skatole.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 1296 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (4)
JECFA Number
1304
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3-METHYL-4,5-BENZOPYRROLE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/55 | FAS 54-JECFA 63/195
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
SKATOLE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/55 | FAS 54-JECFA 63/195
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3-METHYLINDOLE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/55 | FAS 54-JECFA 63/195
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Skatole.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
EINECS 201-471-7
FEMA No. 3019
UNII-9W945B5H7R
3-MI
Skatol
b-Methylindole
beta-methylindole
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
detected; drinking_water; MN Chemical Screening
detected; drinking_water; MN Chemical Screening
detected; drinking_water; MN Chemical Screening
Europe
detected; wastewater
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1329793
Frequently Asked Questions
Is Skatole allowed in the EU?
Skatole EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Skatole do in cosmetics?
Skatole functions as: Fragrance (animalic/fecal/floral note in trace amounts). It is classified as a cosmetic ingredient in our database. CAS number: 83-34-1.
Is Skatole used outside cosmetics?
Skatole also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Skatole compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Same category
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Same category
Fragrance (rich woody, orris/iris roo...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Same category
Fragrance / Perfuming agent with flor...
3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore)
Excellent
Same category
Perfuming / Fragrance (sandalwood note)
4-Tert-Butylcyclohexyl Acetate
Excellent
Same category
Fragrance
Acetoin
Excellent
Same category
Skin conditioning, fragrance
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
1,5-Naphthalenediol
Moderate
Chemical family
Hair dye precursor/coupler — reacts w...
Amylisoeugenol
Moderate
Chemical family
Perfuming
Beta-Sitosterol
Excellent
Chemical family
emulsion stabilising, skin conditioni...
Is Skatole in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Skatole in your formulation.