NOAEL Data REACH Registered Cosmetic Ingredient

Riboflavin

Also known as: Riboflavin (vitamin B2), Vitamin B2 (riboflavin), Aqua-Flave, Benzo(g)pteridine-2,4(3H,10H)-dione, 7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-, Dermadram (+15 more)

CAS 83-88-5

Riboflavin (CAS 83-88-5) is a chemical substance. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for RIBOFLAVIN →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

Riboflavin

CAS Number

83-88-5

DTXSID

DTXSID8021777

Molecular Formula

C17H20N4O6

InChI Key

AUNGANRZJHBGPY-SCRDCRAPSA-N

Monoisotopic Mass

376.138284

Synonyms

Riboflavin (vitamin B2)Vitamin B2 (riboflavin)Aqua-FlaveBenzo(g)pteridine-2,4(3H,10H)-dione, 7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-DermadramEINECS 201-507-1FiboflavinHyflavinIsoalloxazine, 7,8-dimethyl-10-D-ribityl-Isoalloxazine, 7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-D-Ribitol, 1-deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo(g)pteridin-10(2H)-yl)-Riboflavinequinone

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Routes of Exposure	The substance can be absorbed into the body by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 21 records

DyeSoftener and conditionerFlavouring and nutrientPharmaceutical

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 12 records

List	Keyword	Source
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
general_foods	FDA	United States Food and Drug Administration (FDA)
pharmaceutical	US International Trade Commission	CPCat
Europe; supplements	EU	CPCat
Europe; food_additive; supplements	EU	CPCat
Europe; Personal care	European Commission	CosIng
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
Canada; pharmaceutical	DrugBank	DrugBank
Canada; pharmaceutical	DrugBank	DrugBank
Canada; pharmaceutical	DrugBank	DrugBank
active_ingredient; animal_products; Europe; pharmaceutical; residue	EU	CPCat
Europe; supplements	EU	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 16 of 16 studies

Value	Unit	Endpoint	Route	Species	Source
<=0.5	mg/kg	ADI	oral	Human	ToxValDB_WHO_JECFA_ADI
<=0.5	mg/kg bw/day	ADI (group)	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
<=0.5	mg/kg bw/day	ADI (group)	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
TLM2976OFR	UNII	FDA UNII substance identifier	-	-	openFDA substances
TLM2976OFR	UNII	FDA UNII substance identifier	-	-	openFDA substances
TLM2976OFR	UNII	FDA UNII substance identifier	-	-	openFDA substances
TLM2976OFR	UNII	FDA UNII substance identifier	-	-	openFDA substances
>10000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
-	unitless	Model Score	-	-	NTP_ICE_endocrine
4	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
10	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
25	mg/kg bw/day	NOAEL	oral	dog	COSMOS_DB
50	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=160	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=160	mg/kg bw/day	NOAEL	-	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
400	mg/kg bw/day	NOAEL	oral	mouse	COSMOS_DB

Showing 16 of 16 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Riboflavin	201-507-1	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL RIBOFLAVIN

ChEMBL Phase

Adverse Events

4115

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: 0-0.5 mg/kg bw mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Riboflavin?

Riboflavin has 16 NOAEL studies in the database. The lowest reported value is 0.5 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.

What regulatory lists include Riboflavin?

Riboflavin appears on 9 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, general_foods, pharmaceutical, and 6 more. Source: EPA CPDat.

Is Riboflavin used in cosmetics?

Yes, Riboflavin is also indexed as a cosmetic ingredient under the name RIBOFLAVIN. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Riboflavin come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Riboflavin used outside industrial chemicals?

Riboflavin also appears in cosmetics, pharmaceutical, food safety, cannabis databases.