RIBOFLAVIN
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for RIBOFLAVIN. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 400 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
| NOAEL | 400 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 400 mg/kg bw/day | oral | dog | Short Term Toxicity | COSMOS_DB |
| NOAEL | 400 mg/kg bw/day | oral | cat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 400 mg/kg bw/day | oral | rabbit | Short Term Toxicity | COSMOS_DB |
| NOAEL | 25 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 50 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 10 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| NOAEL | 4 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| dose_tested | 400 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Riboflavin is primarily a yellow colorant (CI 75170) with limited skin-active function. Severe photosensitivity is its defining limitation—formulations must use light-protective packaging or the ingredient will degrade rapidly, losing color and co-factor benefit. Systemic B2-acne link not confirmed topically but creates labeling concern for acne-prone products. Use for aesthetic color only; address photostability proactively.
Regulatory Flags
Frequently Asked Questions
Is RIBOFLAVIN safe in cosmetics?
Riboflavin is primarily a yellow colorant (CI 75170) with limited skin-active function. Severe photosensitivity is its defining limitation—formulations must use light-protective packaging or the ingredient will degrade rapidly, losing color and co-factor benefit. Systemic B2-acne link not confirmed topically but creates labeling concern for acne-prone products. Use for aesthetic color only; address photostability proactively. The EU classifies RIBOFLAVIN as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is RIBOFLAVIN allowed in the EU?
RIBOFLAVIN EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does RIBOFLAVIN do in cosmetics?
RIBOFLAVIN functions as: Colorant (CI 75170, yellow); antioxidant co-factor; skin conditioning. It is classified as a Colorant in our database. CAS number: 83-88-5.
What is the Margin of Safety for RIBOFLAVIN?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for RIBOFLAVIN?
The NOAEL (No Observed Adverse Effect Level) for RIBOFLAVIN is 400 mg/kg bw/day based on a Short Term Toxicity study via oral route in mouse. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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