Danger GHS02GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

3-Pentanone

Also known as: EINECS 202-490-3, Ethyl propionyl, Pentanone-3, Diethylcetone, UNII-9SLZ98M9NK

CAS 96-22-0

3-Pentanone (CAS 96-22-0) is a chemical substance with GHS signal word Danger; key hazard signal: H225; H335; H336. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for Diethylketone →

Cross-Vertical Regulatory Divergence

3-Pentanone is classified GHS Danger (H225, H335, H336) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 11 fields

Name

3-Pentanone

CAS Number

96-22-0

DTXSID

DTXSID6021820

Molecular Formula

C5H10O

InChI Key

FDPIMTJIUBPUKL-UHFFFAOYSA-N

Monoisotopic Mass

86.073165

Synonyms

EINECS 202-490-3Ethyl propionylPentanone-3DiethylcetoneUNII-9SLZ98M9NK

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Flam. Liq. 2; STOT SE 3; STOT SE 3	H225; H335; H336	GHS02; GHS07	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Highly flammable liquid and vapour Causes serious eye irritation May cause drowsiness or dizziness May cause respiratory irritation
Short-term Effects	The substance is irritating to the eyes and respiratory tract.
Long-term Effects	The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its vapour.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 5 records

Agency	Metric	Value	ppm	mg/m3	Skin
NIOSH	TWA	200 ppm (705 mg/m³)	200	705	N
ACGIH	TWA	200 ppm [1995]	200	-	N
ACGIH	STEL	300 ppm [1995]	300	-	N
CAL/OSHA	TWA	200 ppm (705 mg/m³)	200	705	N
CAL/OSHA	STEL	300 ppm (1057 mg/m³)	300	1057	N

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records

FragranceFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records

List	Keyword	Source
Europe	European Commission	Fl@vis
IFRA Transparency	IFRA	IFRA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 11 of 11 studies

Value	Unit	Endpoint	Route	Species	Source
=705	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
=708	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
9SLZ98M9NK	UNII	FDA UNII substance identifier	-	-	openFDA substances
9SLZ98M9NK	UNII	FDA UNII substance identifier	-	-	openFDA substances
9SLZ98M9NK	UNII	FDA UNII substance identifier	-	-	openFDA substances
9SLZ98M9NK	UNII	FDA UNII substance identifier	-	-	openFDA substances
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
2700	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
=2140	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=56366.1	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
3	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization

Showing 11 of 11 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Pentan-3-one	202-490-3	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL45315

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for 3-Pentanone?

3-Pentanone (CAS 96-22-0) is classified under EU CLP Annex VI as Flam. Liq. 2; STOT SE 3; STOT SE 3 with signal word Danger. Hazard statements: H225; H335; H336. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 3-Pentanone?

3-Pentanone has 11 NOAEL studies in the database. The lowest reported value is 705 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include 3-Pentanone?

3-Pentanone appears on 2 regulatory/inventory lists including Europe, IFRA Transparency. Source: EPA CPDat.

What are the occupational exposure limits for 3-Pentanone?

Occupational exposure limits for 3-Pentanone are set by NIOSH, ACGIH, CAL/OSHA. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 3-Pentanone used in cosmetics?

Yes, 3-Pentanone is also indexed as a cosmetic ingredient under the name Diethylketone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 3-Pentanone come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 3-Pentanone have different safety status in cosmetics vs industrial chemicals?

3-Pentanone is classified GHS Danger (H225, H335, H336) in the chemicals database but is allowed in EU cosmetics.

Is 3-Pentanone used outside industrial chemicals?

3-Pentanone also appears in cosmetics, pharmaceutical, cannabis databases.