Is Diethylketone safe in cosmetics?
Diethylketone has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Diethylketone
INCI: DIETHYLKETONE
Diethylketone (CAS 96-22-0) is a cosmetic cosmetic ingredient functioning as Perfuming (fragrance). EU Regulation 1223/2009 status: permitted; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 96-22-0 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming (fragrance)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
pentan-3-one
InChIKey
FDPIMTJIUBPUKL-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific prohibition; used in flavors and fragrances
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diethylketone.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
FlamFlameExcl markWarn
Hazard Statements
Highly flammable liquid and vapour Causes serious eye irritation May cause drowsiness or dizziness May cause respiratory irritation
Short-term Exposure Effects
The substance is irritating to the eyes and respiratory tract.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
FlammableHarmful / Irritant
Hazard Class and Category
Flam. Liq. 2; STOT SE 3; STOT SE 3
Hazard Statements
- H225 Highly flammable liquid and vapour
- H335 May cause respiratory irritation
- H336 May cause drowsiness or dizziness
Inserted via ATP: CLP00
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2700 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0874
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
The substance irritates the eyes, the skin and the respiratory tract.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for Diethylketone.
Regulatory Flags
fragrance-component
ifra_fragrance
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL45315
Frequently Asked Questions
Is Diethylketone allowed in the EU?
Diethylketone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethylketone do in cosmetics?
Diethylketone functions as: Perfuming (fragrance). It is classified as a cosmetic ingredient in our database. CAS number: 96-22-0.
Is Diethylketone classified as hazardous under GHS?
Diethylketone carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour Causes serious eye irritation May cause drowsiness or dizziness May cause respiratory irritation. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Diethylketone used outside cosmetics?
Diethylketone also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Diethylketone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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