Also known as: 2-Furanmethanol, tetrahydro-, BRN 0102723, EINECS 202-625-6, FEMA No. 3056, Tetrahydro-2-furfuryl alcohol (+3 more)
CAS 97-99-4
Tetrahydrofurfuryl alcohol (CAS 97-99-4) is a chemical substance with GHS signal word Danger; key hazard signal: H360Df; H319. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
View cosmetic safety profile for Tetrahydrofurfuryl Alcohol →
Tetrahydrofurfuryl alcohol is classified GHS Danger (H360Df, H319) in the chemicals database but is allowed in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Repr. 1B; Eye Irrit. 2 | H360Df; H319 | GHS08; GHS07 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Combustible liquid Causes serious eye irritation Suspected of damaging fertility or the unborn child |
| Short-term Effects | The substance is irritating to the eyes. The substance may cause effects on the central nervous system at high concentrations. This may result in lowering of consciousness. |
| Long-term Effects | Animal tests show that this substance possibly causes toxic effects upon human reproduction. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1.4 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| XD95821VF9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XD95821VF9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XD95821VF9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XD95821VF9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1600 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| <3200 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =159 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =300 | mg/kg bw/day | LOAEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =208.862 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| <37 | mg/kg bw/day | NOAEL | oral | Dog | ToxValDB_ECHA_IUCLID |
| =39 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =40 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =60 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =78 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~96 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg bw/day | NOAEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
| =150 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =300 | mg/kg bw/day | NOAEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
| =500 | ppm | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =760 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =1000 | ppm | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 25 of 25 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Tetrahydrofurfuryl alcohol | 202-625-6 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Tetrahydrofurfuryl alcohol (CAS 97-99-4) is classified under EU CLP Annex VI as Repr. 1B; Eye Irrit. 2 with signal word Danger. Hazard statements: H360Df; H319. Source: EU CLP Annex VI (ECHA).
Tetrahydrofurfuryl alcohol has 25 NOAEL studies in the database. The lowest reported value is 1.4 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Tetrahydrofurfuryl alcohol appears on 6 regulatory/inventory lists including banned; Europe; Personal care, inert_ingredient; non_food_use; Pesticides, IFRA Transparency, and 3 more. Source: EPA CPDat.
Yes, Tetrahydrofurfuryl alcohol is also indexed as a cosmetic ingredient under the name Tetrahydrofurfuryl Alcohol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Tetrahydrofurfuryl alcohol is classified GHS Danger (H360Df, H319) in the chemicals database but is allowed in EU cosmetics.
Tetrahydrofurfuryl alcohol also appears in cosmetics, pharmaceutical, cannabis databases.