Food Safety Substance
Cellulase
Cellulase is a food additive with yes in the EU, FDA has no questions in the US, and data from 7 regulatory sources.
CAS 9012-54-8
Indexable evidence set
FDA
FDA has no questions
ADI / TDI
JECFA ADI NO ADI ALLOCATED
Codex
0 row(s)
SOURCE
D1 identity resolution
e number aliases | Food Additives | dsstox identifiers | 7 matched regulatory source group(s)
Substance Identity
Resolved identifiers used to render this food-safety record.
Substance name
Cellulase
CAS
9012-54-8
DTXSID
DTXSID2049638
Evidence tier
Indexable evidence set (8)
SOURCE
EU Commission
FDA | Health Canada | Codex Alimentarius
Multi-Jurisdiction Comparison
Side-by-side status rows for the same resolved substance across public food regulators.
| Jurisdiction | Authority | Status | Evidence |
|---|---|---|---|
| European Union | EU Commission | yes | - |
| United States | FDA | FDA has no questions | GRAS notice |
| Canada | Health Canada | Listed | Food enzyme |
SOURCE
FDA
FDA GRAS
FDA GRAS Status
US FDA GRAS notice evidence from enriched and notice tables.
| Jurisdiction | GRN | Substance | FDA response | Intended use | Basis | Notifier |
|---|---|---|---|---|---|---|
| United States | 292 | Cellulase enzyme preparation derived from a genetically modified strain of Myceliophthora thermophila | FDA has no questions | Enzyme in the production of wine, beer and fruit juices | Scientific procedures | Dyadic International (USA) Inc. |
| United States | 479 | Beta-glucanase, cellulase, and xylanase enzyme preparation from Talaromyces emersonii | FDA has no questions | As an enzyme in the production of beer and fermented beverages at levels up to 500 grams per metric ton of grist | Scientific procedures | DSM Food Specialties |
| United States | 584 | Cellulase from Penicillium funiculosum | FDA has no questions | For use as a processing aid in brewing, baking and potable alcohol production. | Scientific procedures | Danisco US Inc. |
| United States | 891 | Cellulase produced by Trichoderma reesei | FDA has no questions | Intended for use as an enzyme in fruit and vegetable processing, wine processing, starch and grain processing, brewing and other cereal based beverages and potable/fuel alcohol. | Scientific procedures | Novozymes North America Inc. |
| United States | 1030 | Cellulase enzyme preparation produced by Aspergillus niger genetically engineered to express a cellulase gene from Trichoderma reesei | FDA has no questions | Intended for use as an enzyme at a maximum level of 100 mg total organic solids/kg raw material in brewing, processing of other cereal based beverages, fruits and vegetables... | Scientific procedures | Novozymes North America Inc. |
| United States | 1276 | Cellulase enzyme preparation produced by Trichoderma reesei expressing a gene encoding a cellulase from Aspergillus niger | Pending | Intended for use as an enzyme at up to 19 mg Total Organic Solids (TOS)/kg cereals in the production of baked goods, beer, and malt. | Scientific procedures | AB Enzymes Inc. |
| United States | 292 | Cellulase enzyme preparation derived from a genetically modified strain of <i>Myceliophthora thermophila</i> | FDA has no questions | Enzyme in the production of wine, beer and fruit juices | Scientific procedures | Dyadic International (USA) Inc. |
| United States | 479 | Beta-glucanase, cellulase, and xylanase enzyme preparation from <i>Talaromyces emersonii</i> | FDA has no questions | As an enzyme in the production of beer and fermented beverages at levels up to 500 grams per metric ton of grist | Scientific procedures | DSM Food Specialties |
| United States | 584 | Cellulase from <i>Penicillium funiculosum</i> | FDA has no questions | For use as a processing aid in brewing, baking and potable alcohol production. | Scientific procedures | Danisco US Inc. |
| United States | 891 | Cellulase produced by <i>Trichoderma reesei</i> | FDA has no questions (in PDF) | Intended for use as an enzyme in fruit and vegetable processing, wine processing, starch and grain processing, brewing and other cereal based beverages and potable/fuel alcohol. | Scientific procedures | Novozymes North America Inc. |
| United States | 1030 | Cellulase enzyme preparation produced by <i>Aspergillus niger</i> genetically engineered to express a cellulase gene from <i>Trichoderma reesei</i> | FDA has no questions (in PDF) | Intended for use as an enzyme at a maximum level of 100 mg total organic solids/kg raw material in brewing, processing of other cereal based beverages, fruits and vegetables... | Scientific procedures | Novozymes North America Inc. |
| United States | 1276 | Cellulase enzyme preparation produced by <i>Trichoderma reesei</i> expressing a gene encoding a cellulase from <i>Aspergillus niger</i> | Pending | Intended for use as an enzyme at up to 19 mg Total Organic Solids (TOS)/kg cereals in the production of baked goods, beer, and malt. | Scientific procedures | AB Enzymes Inc. |
SOURCE
Health Canada
Health Canada Status
Health Canada food-additive permissions by functional class and food scope.
| Jurisdiction | Class | Permitted foods | Maximum level | List |
|---|---|---|---|---|
| Canada | Food enzyme | (a) Distillers' mash | (a) Good Manufacturing Practice | List of Permitted Food Enzymes |
| Canada | Food enzyme | (b) Liquid coffee concentrates | (b) Good Manufacturing Practice | List of Permitted Food Enzymes |
| Canada | Food enzyme | (c) Natural flavour and colour extractives; Spice extracts | (c) Good Manufacturing Practice | List of Permitted Food Enzymes |
| Canada | Food enzyme | (a) Bread; White flour; Whole wheat flour | (a) Good Manufacturing Practice | List of Permitted Food Enzymes |
| Canada | Food enzyme | (b) Breakfast cereals | (b) Good Manufacturing Practice | List of Permitted Food Enzymes |
| Canada | Food enzyme | (c) Brewers' mash | (c) Good Manufacturing Practice | List of Permitted Food Enzymes |
| Canada | Food enzyme | (d) Malt extract | (d) Good Manufacturing Practice | List of Permitted Food Enzymes |
| Canada | Food enzyme | (e) Plant-based products that resemble dairy products; Plant-based products that resemble dairy-based products; Plant-based products that resemble meat products, including simulated meat products; Plant-based products... | (e) Good Manufacturing Practice | List of Permitted Food Enzymes |
| Canada | Food enzyme | (f) Unstandardized bakery products | (f) Good Manufacturing Practice | List of Permitted Food Enzymes |
| Canada | Food enzyme | (a) Apple juice; Grape juice; Grapefruit juice; Lemon juice; Lime juice; (Naming the fruit) juice; Orange juice; Pineapple juice | (a) Good Manufacturing Practice | List of Permitted Food Enzymes |
| Canada | Food enzyme | (b) Bread; White flour; Whole wheat flour | (b) Good Manufacturing Practice | List of Permitted Food Enzymes |
| Canada | Food enzyme | (c) Unstandardized bakery products | (c) Good Manufacturing Practice | List of Permitted Food Enzymes |
| Canada | Food enzyme | (a) Apricot nectar; Peach nectar; Pear nectar | (a) Good Manufacturing Practice | List of Permitted Food Enzymes |
| Canada | Food enzyme | (b) Single-strength fruit juices | (b) Good Manufacturing Practice | List of Permitted Food Enzymes |
| Canada | Food enzyme | (c) Tea leaves used in the manufacture of tea solids | (c) Good Manufacturing Practice | List of Permitted Food Enzymes |
| Canada | Food enzyme | (d) Unstandardized fruit and vegetable products | (d) Good Manufacturing Practice | List of Permitted Food Enzymes |
| Canada | Food enzyme | (a) Brewers' mash | (a) Good Manufacturing Practice | List of Permitted Food Enzymes |
| Canada | Food enzyme | (b) Distillers' mash | (b) Good Manufacturing Practice | List of Permitted Food Enzymes |
| Canada | Food enzyme | (a) Distillers' mash | (a) Good Manufacturing Practice | List of Permitted Food Enzymes |
| Canada | Food enzyme | (b) Liquid coffee concentrates | (b) Good Manufacturing Practice | List of Permitted Food Enzymes |
| Canada | Food enzyme | (c) Mash destined for vinegar manufacture | (c) Good Manufacturing Practice | List of Permitted Food Enzymes |
SOURCE
JECFA
JECFA ADI
JECFA ADI Values
JECFA ADI records and evaluation years.
| Jurisdiction | Chemical name | JECFA no. | CAS | ADI | ADI upper | Function | Evaluation year |
|---|---|---|---|---|---|---|---|
| JECFA | TRICHODERMA REESEI CELLULASE | - | - | no_data | - | - | 1992 |
| JECFA | ASPERGILLUS NIGER, VAR. HEMICELLULASE | - | - | no_data | - | - | 1989 |
| JECFA | CELLULASE from PENICILLIUM FUNICULOSUM | - | - | NO ADI ALLOCATED | - | ENZYME_PREPARATION | 1987 |
| JECFA | CELLULASE from TRICHODERMA LONGIBRACHIATUM | - | - | NOT SPECIFIED | - | ENZYME_PREPARATION | 1992 |
| JECFA | HEMICELLULASE from ASPERGILLUS NIGER, VAR. | - | - | NOT SPECIFIED | - | ENZYME_PREPARATION | 1989 |
| JECFA | TRICHODERMA LONGIBRACHIATUM CELLULASE | - | - | no_data | - | - | 1992 |
| JECFA | PENICILLIUM FUNICULOSUM CELLULASE | - | - | no_data | - | - | 1987 |
| JECFA | CELLULASE FROM TRICHODERMA REESEI | - | - | no_data | - | - | 1992 |
| JECFA | Mixed Β-GLUCANASE, CELLULASE and XYLANASE from RASAMSONIA EMERSONI | - | 62213-14-3; 9012-54-8; 9025-57-4 | NOT SPECIFIED | - | ENZYME_PREPARATION | 2015 |
SOURCE
ingredients
ghs classifications
Cross-Reference to Cosmetics / Chemicals / Pharma
Same-CAS public rows from adjacent Roots verticals where available.
SOURCE
Cross-vertical comparison
ingredients | ghs classifications
Cross-Vertical Regulatory Divergence
This substance has different regulatory treatment across food, cosmetics, and industrial use.
SOURCE
FAQPage JSON-LD
public food renderer rows
Frequently Asked Questions
Food-use, safety, ADI, and cross-vertical answers mirrored into FAQPage JSON-LD.
What is Cellulase used for in food?
Cellulase appears in food-use rows as: Fiber modification, juice processing; Food enzyme.
Is Cellulase safe?
This page does not assign a standalone safety verdict; it renders public regulatory evidence. ADI/reference value: JECFA ADI NO ADI ALLOCATED. EU status evidence: yes. US/FDA evidence: FDA has no questions.
What is the ADI for Cellulase?
Cellulase has this ADI/reference value in the food-safety tables: JECFA ADI NO ADI ALLOCATED. Source: JECFA 1987.
Is Cellulase also used in cosmetics?
Cellulase has a same-CAS cosmetics cross-reference: Cellulase, EU status permitted.