Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Cellulase. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=1013.3 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Enzyme activity requires strict pH and temperature control; potential skin irritation at high concentrations and occupational allergenicity risk via inhalation.
Regulatory Flags
Frequently Asked Questions
Is Cellulase safe in cosmetics?
Enzyme activity requires strict pH and temperature control; potential skin irritation at high concentrations and occupational allergenicity risk via inhalation. The EU classifies Cellulase as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.
Is Cellulase allowed in the EU?
Cellulase EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cellulase do in cosmetics?
Cellulase functions as: Skin conditioning (enzyme-based exfoliation). It is classified as a cosmetic ingredient in our database. CAS number: 9012-54-8.
What is the Margin of Safety for Cellulase?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Cellulase?
The NOAEL (No Observed Adverse Effect Level) for Cellulase is >=1013.3 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
Check Cellulase compliance across multiple jurisdictions:
Related Ingredients
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