Also known as: 4,5-Diamino-1-n-hexyl-1H-pyrazole hemisulfate
INCI: 1-HEXYL 4,5-DIAMINO PYRAZOLE SULFATE
1-Hexyl 4,5-Diamino Pyrazole Sulfate (CAS 1361000-03-4) is a cosmetic cosmetic ingredient functioning as Hair dyeing — oxidative hair colouring agent (precursor). Reported NOAEL =5 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 1361000-03-4 →
1-Hexyl 4,5-Diamino Pyrazole Sulfate is classified GHS Danger (H301, H331, H312, H317, H372, H411) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for 1-Hexyl 4,5-Diamino Pyrazole Sulfate.
Calculate MoS for your specific formulation with the MoS Calculator.
1 study endpoint found for 1-Hexyl 4,5-Diamino Pyrazole Sulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =5 mg/kg bw/day | oral | Rat | subchronic | ECHA |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Preliminary editorial summary for 1-Hexyl 4,5-Diamino Pyrazole Sulfate — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to 1-Hexyl 4,5-Diamino Pyrazole Sulfate by CAS number or substance name.
1-Hexyl 4,5-Diamino Pyrazole Sulfate has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
1-Hexyl 4,5-Diamino Pyrazole Sulfate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
1-Hexyl 4,5-Diamino Pyrazole Sulfate functions as: Hair dyeing — oxidative hair colouring agent (precursor). It is classified as a cosmetic ingredient in our database. CAS number: 1361000-03-4.
The NOAEL (No Observed Adverse Effect Level) for 1-Hexyl 4,5-Diamino Pyrazole Sulfate is =5 mg/kg bw/day based on a subchronic study via oral route in Rat. Source: ECHA.
1-Hexyl 4,5-Diamino Pyrazole Sulfate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
1-Hexyl 4,5-Diamino Pyrazole Sulfate is classified GHS Danger (H301, H331, H312, H317, H372, H411) in the chemicals database but is restricted in EU cosmetics.
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