Good Cosmetic Ingredient NOAEL Data

1,3-Dimethyl-3-Phenylbutyl Acetate

INCI: 1,3-DIMETHYL-3-PHENYLBUTYL ACETATE

CAS Number
68083-58-9
Function
Fragrance ingredient
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; regulated under FEMA/IFRA frameworks for fragrance use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for 1,3-Dimethyl-3-Phenylbutyl Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOEL ca.100 mg/kg bw/day oral rat oral REACH
NOEL ca.100 mg/kg bw/day oral - oral REACH

Expert Verdict

Fragrance ingredient used in perfumes, shampoos, fabric softeners, and deodorants with no major safety alerts; standard fragrance precautions apply.

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Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance

Frequently Asked Questions

Is 1,3-Dimethyl-3-Phenylbutyl Acetate safe in cosmetics?

Fragrance ingredient used in perfumes, shampoos, fabric softeners, and deodorants with no major safety alerts; standard fragrance precautions apply. The EU classifies 1,3-Dimethyl-3-Phenylbutyl Acetate as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is 1,3-Dimethyl-3-Phenylbutyl Acetate allowed in the EU?

1,3-Dimethyl-3-Phenylbutyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 1,3-Dimethyl-3-Phenylbutyl Acetate do in cosmetics?

1,3-Dimethyl-3-Phenylbutyl Acetate functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 68083-58-9.

What is the Margin of Safety for 1,3-Dimethyl-3-Phenylbutyl Acetate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 1,3-Dimethyl-3-Phenylbutyl Acetate?

The NOAEL (No Observed Adverse Effect Level) for 1,3-Dimethyl-3-Phenylbutyl Acetate is ca.100 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

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