Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for 1,5-Pentanediol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 400 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
CIR concluded safety for 1,5-Pentanediol among a group of alkane diols.
Regulatory Flags
Frequently Asked Questions
Is 1,5-Pentanediol safe in cosmetics?
CIR concluded safety for 1,5-Pentanediol among a group of alkane diols. The EU classifies 1,5-Pentanediol as "permitted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.
Is 1,5-Pentanediol allowed in the EU?
1,5-Pentanediol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 1,5-Pentanediol do in cosmetics?
1,5-Pentanediol functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 111-29-5.
What is the Margin of Safety for 1,5-Pentanediol?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 1,5-Pentanediol?
The NOAEL (No Observed Adverse Effect Level) for 1,5-Pentanediol is 1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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