Moderate Cosmetic Ingredient NOAEL Data

2-(2-Aminoethoxy)Ethanol

INCI: 2-(2-AMINOETHOXY)ETHANOL

CAS Number
929-06-6
Function
Buffering (pH adjustment)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not specifically restricted; FDA guidance warns against nitrosamine formation with DEA/TEA-type amines in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for 2-(2-Aminoethoxy)Ethanol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 17 mg/kg bw/day dermal rat dermal REACH
NOAEL 340 mg/kg bw/day oral rat oral REACH
NOAEL 15000 ppm oral rat oral REACH
NOAEL 250 mg/kg bw/day dermal rat dermal REACH

Expert Verdict

Nitrosamine formation risk when combined with nitrosating agents; must verify no nitrosamine contamination in finished product.

โš ๏ธ
Concern Level: Moderate

Frequently Asked Questions

Is 2-(2-Aminoethoxy)Ethanol safe in cosmetics?

Nitrosamine formation risk when combined with nitrosating agents; must verify no nitrosamine contamination in finished product. The EU classifies 2-(2-Aminoethoxy)Ethanol as "permitted". Safety rating: MODERATE. 4 toxicological study endpoint(s) are available in our database.

Is 2-(2-Aminoethoxy)Ethanol allowed in the EU?

2-(2-Aminoethoxy)Ethanol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 2-(2-Aminoethoxy)Ethanol do in cosmetics?

2-(2-Aminoethoxy)Ethanol functions as: Buffering (pH adjustment). It is classified as a cosmetic ingredient in our database. CAS number: 929-06-6.

What is the Margin of Safety for 2-(2-Aminoethoxy)Ethanol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 2-(2-Aminoethoxy)Ethanol?

The NOAEL (No Observed Adverse Effect Level) for 2-(2-Aminoethoxy)Ethanol is 17 mg/kg bw/day based on a dermal study via dermal route in rat. A total of 4 study endpoints are available. Source: REACH.

๐Ÿ“ฑ

Is 2-(2-Aminoethoxy)Ethanol in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 2-(2-Aminoethoxy)Ethanol in your formulation.