Is 2-(2-Aminoethoxy)Ethanol safe in cosmetics?
2-(2-Aminoethoxy)Ethanol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
2-(2-Aminoethoxy)Ethanol
Also known as: 4-04-00-01412, 2-Aminoethoxyethanol, BRN 0906728, EINECS 213-195-4, beta-Hydroxy-beta'-aminoethyl ether (+4 more)
INCI: 2-(2-AMINOETHOXY)ETHANOL
2-(2-Aminoethoxy)Ethanol (CAS 929-06-6) is a cosmetic cosmetic ingredient functioning as Buffering (pH adjustment). NOAEL 340 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 929-06-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2-(2-Aminoethoxy)Ethanol is classified GHS Danger (H290, H314, H318) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Buffering (pH adjustment)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-(2-aminoethoxy)ethanol
InChIKey
GIAFURWZWWWBQT-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically restricted; FDA guidance warns against nitrosamine formation with DEA/TEA-type amines in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-(2-Aminoethoxy)Ethanol.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 2-(2-Aminoethoxy)Ethanol across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
STRONG IRRITANT TO TISSUE.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Hair fixative
Expert Verdict
Expert safety assessment and concern-level summary for 2-(2-Aminoethoxy)Ethanol.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 2-(2-Aminoethoxy)Ethanol by CAS number or substance name.
Studies
12
Lowest NOAEL
17 mg/kg bw/day
Highest NOAEL
340 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
4-04-00-01412
2-Aminoethoxyethanol
BRN 0906728
EINECS 213-195-4
beta-Hydroxy-beta'-aminoethyl ether
beta-(beta-Hydroxyethoxy)ethylamine
5-Aminoethyl 2-hydroxyethyl ether
beta-Hydroxy-beta'-aminodiethyl ether
UNII-6R5Y84T8W9
Chemical Function
Hair fixative
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3183757
Frequently Asked Questions
Is 2-(2-Aminoethoxy)Ethanol allowed in the EU?
2-(2-Aminoethoxy)Ethanol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-(2-Aminoethoxy)Ethanol do in cosmetics?
2-(2-Aminoethoxy)Ethanol functions as: Buffering (pH adjustment). It is classified as a cosmetic ingredient in our database. CAS number: 929-06-6.
Is 2-(2-Aminoethoxy)Ethanol used outside cosmetics?
2-(2-Aminoethoxy)Ethanol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2-(2-Aminoethoxy)Ethanol have different safety status in cosmetics vs industrial chemicals?
2-(2-Aminoethoxy)Ethanol is classified GHS Danger (H290, H314, H318) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check 2-(2-Aminoethoxy)Ethanol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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