Is 2,5-DIHYDROXYBENZOIC ACID safe in cosmetics?
2,5-DIHYDROXYBENZOIC ACID has a safety rating of "GOOD" in our database. EU status: permitted.
Good
Cosmetic Ingredient
2,5-DIHYDROXYBENZOIC ACID
Also known as: 4-10-00-01441, BRN 2209119, EINECS 207-718-5, Gentisate, Salicylic acid, 5-hydroxy- (+13 more)
2,5-DIHYDROXYBENZOIC ACID (CAS 490-79-9) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 490-79-9 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2,5-dihydroxybenzoic acid
InChIKey
WXTMDXOMEHJXQO-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
EPA ToxValDB — Toxicity Values
1 toxicity value from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | =4500 mg/kg | Mouse | oral | - | ChemIDplus |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for 2,5-DIHYDROXYBENZOIC ACID.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
needs-enrichment
Known Synonyms
4-10-00-01441
BRN 2209119
EINECS 207-718-5
Gentisate
Salicylic acid, 5-hydroxy-
Acido 2,5-diidrossibenzoico
Acidum gentisicum
Kyselina 2,5-dihydroxybenzoova
Kyselina gentisinova
UNII-VP36V95O3T
2,5-Dioxybenzoate
3,6-Dihydroxybenzoate
5-Hydroxy-Salicylate
5-Hydroxy-Salicylic acid
5-Hydroxysalicylate
Dihydroxybenzoicacid
Gentisinate
Hydroquinonecarboxylate
Chemical Function
Softener and conditioner
Regulatory Lists
pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
GENTISIC ACID
ChEMBL ID
CHEMBL1461
Frequently Asked Questions
Is 2,5-DIHYDROXYBENZOIC ACID allowed in the EU?
2,5-DIHYDROXYBENZOIC ACID EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2,5-DIHYDROXYBENZOIC ACID do in cosmetics?
2,5-DIHYDROXYBENZOIC ACID functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 490-79-9.
Is 2,5-DIHYDROXYBENZOIC ACID used outside cosmetics?
2,5-DIHYDROXYBENZOIC ACID also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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