1-Methylhydantoin-2-imide (Creatinine)

INCI: 1-METHYLHYDANTOIN-2-IMIDE

CAS Number
60-27-5
Function
Skin conditioning (skin brightening/lightening agent; reduces melanin appearance)
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; endogenous metabolite with no restrictions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

None; this is creatinine - a normal metabolic byproduct; EWG rated safe ; recommended concentration 0.5-1.0%

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Concern Level: None

Frequently Asked Questions

Is 1-Methylhydantoin-2-imide (Creatinine) safe in cosmetics?

None; this is creatinine - a normal metabolic byproduct; EWG rated safe ; recommended concentration 0.5-1.0% The EU classifies 1-Methylhydantoin-2-imide (Creatinine) as "permitted". Safety rating: EXCELLENT.

Is 1-Methylhydantoin-2-imide (Creatinine) allowed in the EU?

1-Methylhydantoin-2-imide (Creatinine) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 1-Methylhydantoin-2-imide (Creatinine) do in cosmetics?

1-Methylhydantoin-2-imide (Creatinine) functions as: Skin conditioning (skin brightening/lightening agent; reduces melanin appearance). It is classified as a cosmetic ingredient in our database. CAS number: 60-27-5.

What is the Margin of Safety for 1-Methylhydantoin-2-imide (Creatinine)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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