Is 1-Methylhydantoin-2-imide (Creatinine) safe in cosmetics?
1-Methylhydantoin-2-imide (Creatinine) has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
1-Methylhydantoin-2-imide (Creatinine)
Also known as: Creatinine,heated, EINECS 200-466-7, UNII-AYI8EX34EU, 2-amino-1-methyl-5H-imidazol-4-one, Creatine anhydride (+2 more)
INCI: 1-METHYLHYDANTOIN-2-IMIDE
1-Methylhydantoin-2-imide (Creatinine) (CAS 60-27-5) is a cosmetic cosmetic ingredient functioning as Skin conditioning (skin brightening/lightening agent; reduces melanin. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 60-27-5 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning (skin brightening/lightening agent; reduces melanin appearance)
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
2-amino-3-methyl-4H-imidazol-5-one
InChIKey
DDRJAANPRJIHGJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; endogenous metabolite with no restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 1-Methylhydantoin-2-imide (Creatinine).
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for 1-Methylhydantoin-2-imide (Creatinine).
Known Synonyms
Creatinine,heated
EINECS 200-466-7
UNII-AYI8EX34EU
2-amino-1-methyl-5H-imidazol-4-one
Creatine anhydride
Kreatinin
creatinina
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CREATININE
ChEMBL ID
CHEMBL65567
Max Phase
3
Adverse Event Associations
41
Frequently Asked Questions
Is 1-Methylhydantoin-2-imide (Creatinine) allowed in the EU?
1-Methylhydantoin-2-imide (Creatinine) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 1-Methylhydantoin-2-imide (Creatinine) do in cosmetics?
1-Methylhydantoin-2-imide (Creatinine) functions as: Skin conditioning (skin brightening/lightening agent; reduces melanin appearance). It is classified as a cosmetic ingredient in our database. CAS number: 60-27-5.
Is 1-Methylhydantoin-2-imide (Creatinine) used outside cosmetics?
1-Methylhydantoin-2-imide (Creatinine) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 1-Methylhydantoin-2-imide (Creatinine) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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