Good Cosmetic Ingredient NOAEL Data

2-Phenylpropyltetrahydrofuran

INCI: 2-PHENYLPROPYLTETRAHYDROFURAN

CAS Number
3208-40-0
Function
Perfuming
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No specific FDA restriction; RIFM safety assessment exists

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for 2-Phenylpropyltetrahydrofuran. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 48.58 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 48.58 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

No significant safety concerns per RIFM evaluation.

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Concern Level: Low

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive

Frequently Asked Questions

Is 2-Phenylpropyltetrahydrofuran safe in cosmetics?

No significant safety concerns per RIFM evaluation. The EU classifies 2-Phenylpropyltetrahydrofuran as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is 2-Phenylpropyltetrahydrofuran allowed in the EU?

2-Phenylpropyltetrahydrofuran EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 2-Phenylpropyltetrahydrofuran do in cosmetics?

2-Phenylpropyltetrahydrofuran functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 3208-40-0.

What is the Margin of Safety for 2-Phenylpropyltetrahydrofuran?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for 2-Phenylpropyltetrahydrofuran?

The NOAEL (No Observed Adverse Effect Level) for 2-Phenylpropyltetrahydrofuran is 48.58 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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