Is 2,6-Dicarboxypyridine (Dipicolinic Acid) safe in cosmetics?
2,6-Dicarboxypyridine (Dipicolinic Acid) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
2,6-Dicarboxypyridine (Dipicolinic Acid)
Also known as: Dipicolinate, EINECS 207-894-3, UNII-UE81S5CQ0G
INCI: DIPICOLINIC ACID
2,6-Dicarboxypyridine (Dipicolinic Acid) (CAS 499-83-2) is a cosmetic cosmetic ingredient functioning as Chelating agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 499-83-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2,6-Dicarboxypyridine (Dipicolinic Acid) is classified GHS Danger (H314, H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Chelating agent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
pyridine-2,6-dicarboxylic acid
InChIKey
WJJMNDUMQPNECX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific FDA cosmetic restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2,6-Dicarboxypyridine (Dipicolinic Acid).
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for 2,6-Dicarboxypyridine (Dipicolinic Acid).
Regulatory Flags
natural-origin
Known Synonyms
Dipicolinate
EINECS 207-894-3
UNII-UE81S5CQ0G
Chemical Function
Chelating agent
Regulatory Lists
CEDI
Indirect additives food contact (10/2018)
Raw materials
inert_ingredient; non_food_use; Pesticides
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DIPICOLINIC ACID
ChEMBL ID
CHEMBL284104
Frequently Asked Questions
Is 2,6-Dicarboxypyridine (Dipicolinic Acid) allowed in the EU?
2,6-Dicarboxypyridine (Dipicolinic Acid) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2,6-Dicarboxypyridine (Dipicolinic Acid) do in cosmetics?
2,6-Dicarboxypyridine (Dipicolinic Acid) functions as: Chelating agent. It is classified as a cosmetic ingredient in our database. CAS number: 499-83-2.
Is 2,6-Dicarboxypyridine (Dipicolinic Acid) used outside cosmetics?
2,6-Dicarboxypyridine (Dipicolinic Acid) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2,6-Dicarboxypyridine (Dipicolinic Acid) have different safety status in cosmetics vs industrial chemicals?
2,6-Dicarboxypyridine (Dipicolinic Acid) is classified GHS Danger (H314, H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check 2,6-Dicarboxypyridine (Dipicolinic Acid) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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