3,4-Methylenedioxyphenol

INCI: 3,4-METHYLENEDIOXYPHENOL

CAS Number
533-31-3
Function
Hair dye precursor, Antioxidant
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not on FDA's prohibited list for general cosmetic use; however, limited cosmetic application

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Restricted in EU (Annex III) for hair dye use due to skin irritant classification (H315) at high concentrations; methylenedioxy moiety raises metabolic concern regarding potential CYP inhibition.

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Concern Level: Moderate

Regulatory Flags

eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is 3,4-Methylenedioxyphenol safe in cosmetics?

Restricted in EU (Annex III) for hair dye use due to skin irritant classification (H315) at high concentrations; methylenedioxy moiety raises metabolic concern regarding potential CYP inhibition. The EU classifies 3,4-Methylenedioxyphenol as "restricted". Safety rating: MODERATE.

Is 3,4-Methylenedioxyphenol allowed in the EU?

3,4-Methylenedioxyphenol EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does 3,4-Methylenedioxyphenol do in cosmetics?

3,4-Methylenedioxyphenol functions as: Hair dye precursor, Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 533-31-3.

What is the Margin of Safety for 3,4-Methylenedioxyphenol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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