Is 4'-Methoxychalcone safe in cosmetics?
4'-Methoxychalcone has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
MODERATE
Cosmetic Ingredient
4'-Methoxychalcone
Also known as: 2-Propen-1-one, 1-(4-methoxyphenyl)-3-phenyl-, alpha-Styryl p-anisyl ketone, EINECS 213-495-5
INCI: 4'-METHOXYCHALCONE
4'-Methoxychalcone (CAS 959-23-9) is a cosmetic cosmetic ingredient functioning as Antioxidant, Bleaching (skin lightening), Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Function
Antioxidant, Bleaching (skin lightening), Skin Conditioning
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
(E)-1-(4-methoxyphenyl)-3-phenylprop-2-en-1-one
InChIKey
KJHHAPASNNVTSN-KPKJPENVSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA restriction; not a color additive; permissible under general safety provisions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 4'-Methoxychalcone.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Bleaching agent
Softener and conditioner
Editorial summary
Preliminary editorial summary for 4'-Methoxychalcone — not a computed safety verdict. See the sourced toxicological data above.
Known Synonyms
2-Propen-1-one, 1-(4-methoxyphenyl)-3-phenyl-
alpha-Styryl p-anisyl ketone
EINECS 213-495-5
Chemical Function
Antioxidant
Softener and conditioner
Bleaching agent
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
4'-METHOXYCHALCONE
ChEMBL ID
CHEMBL34398
Frequently Asked Questions
Is 4'-Methoxychalcone allowed in the EU?
4'-Methoxychalcone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 4'-Methoxychalcone do in cosmetics?
4'-Methoxychalcone functions as: Antioxidant, Bleaching (skin lightening), Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 959-23-9.
Is 4'-Methoxychalcone used outside cosmetics?
4'-Methoxychalcone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 4'-Methoxychalcone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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