4'-Methoxychalcone

INCI: 4'-METHOXYCHALCONE

CAS Number
959-23-9
Function
Antioxidant, Bleaching (skin lightening), Skin Conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No specific FDA restriction; not a color additive; permissible under general safety provisions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Phototoxicity concern with PIF = 10.19 and MPE = 0.428 comparable to chlorpromazine; ecotoxic in Microtox assay (EC50 = 0.0047 mg/L at 5 min); non-irritant at 2% in PEG; not genotoxic in micronucleus test.

โš ๏ธ
Concern Level: High

Frequently Asked Questions

Is 4'-Methoxychalcone safe in cosmetics?

Phototoxicity concern with PIF = 10.19 and MPE = 0.428 comparable to chlorpromazine; ecotoxic in Microtox assay (EC50 = 0.0047 mg/L at 5 min); non-irritant at 2% in PEG; not genotoxic in micronucleus test. The EU classifies 4'-Methoxychalcone as "permitted". Safety rating: MODERATE.

Is 4'-Methoxychalcone allowed in the EU?

4'-Methoxychalcone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does 4'-Methoxychalcone do in cosmetics?

4'-Methoxychalcone functions as: Antioxidant, Bleaching (skin lightening), Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 959-23-9.

What is the Margin of Safety for 4'-Methoxychalcone?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is 4'-Methoxychalcone in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 4'-Methoxychalcone in your formulation.