Is 4'-Methoxychalcone safe in cosmetics?
4'-Methoxychalcone has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
4'-Methoxychalcone
Also known as: 2-Propen-1-one, 1-(4-methoxyphenyl)-3-phenyl-, alpha-Styryl p-anisyl ketone, EINECS 213-495-5
INCI: 4'-METHOXYCHALCONE
4'-Methoxychalcone (CAS 959-23-9) is a cosmetic cosmetic ingredient functioning as Antioxidant, Bleaching (skin lightening), Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 959-23-9 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, Bleaching (skin lightening), Skin Conditioning
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(E)-1-(4-methoxyphenyl)-3-phenylprop-2-en-1-one
InChIKey
KJHHAPASNNVTSN-KPKJPENVSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA restriction; not a color additive; permissible under general safety provisions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 4'-Methoxychalcone.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Bleaching agent
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for 4'-Methoxychalcone.
Known Synonyms
2-Propen-1-one, 1-(4-methoxyphenyl)-3-phenyl-
alpha-Styryl p-anisyl ketone
EINECS 213-495-5
Chemical Function
Antioxidant
Softener and conditioner
Bleaching agent
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
4'-METHOXYCHALCONE
ChEMBL ID
CHEMBL34398
Frequently Asked Questions
Is 4'-Methoxychalcone allowed in the EU?
4'-Methoxychalcone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 4'-Methoxychalcone do in cosmetics?
4'-Methoxychalcone functions as: Antioxidant, Bleaching (skin lightening), Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 959-23-9.
Is 4'-Methoxychalcone used outside cosmetics?
4'-Methoxychalcone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check 4'-Methoxychalcone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2-O-Ethyl Ascorbic Acid
Excellent
Same category
Softener and conditioner
3-Glyceryl Ascorbate
Excellent
Same category
Antioxidant, Humectant, Skin Conditio...
Allantoin Ascorbate
Excellent
Same category
Antioxidant, Skin Conditioning, Skin ...
Aloe Vera Extract
Excellent
Same category
Skin Conditioning, Antioxidant
Althaea Officinalis Callus Culture Extract
Excellent
Same category
Antioxidant, skin protectant
Amaranthus Caudatus Seed Oil
Excellent
Same category
Emollient, skin conditioning, antioxi...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(SH-Pentapeptide-10 6-Aminocaprooyl SH-Pentapeptide-11) SP
Moderate
Similar safety
Skin/hair conditioning (peptide-based...
1,2,3,4,4a,5,6,7-Octahydro-2,5,5-Trimethyl-2-Naphthol
Moderate
Similar safety
Fragrance ingredient
Caprylylalkonium Chloride
Moderate
Chemical family
Hair conditioning, antistatic
4,4'-Diaminodiphenylamine
Poor
Browse nearby
Hair Dye (oxidative)
4,4'-Diaminodiphenylamine Sulfate
Poor
Browse nearby
Hair Dye (oxidative)
Is 4'-Methoxychalcone in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 4'-Methoxychalcone in your formulation.